Integrin β1/ITGB1 Antibody (102DF5): sc-73610

Integrin β1 Antibody (102DF5) is a mouse monoclonal IgG1 antibody that detects Integrin β1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Integrin β1 plays a crucial role in cell adhesion and signaling, functioning as a key component of the integrin family of receptors that mediate interactions between cells and the extracellular matrix. Integrin β1 is primarily located on the cell surface, where Integrin β1 forms heterodimers with various α subunits, allowing binding to ligands such as fibronectin and collagen. Proper localization of Integrin β1 is essential for maintaining tissue architecture and facilitating cellular communication, as Integrin β1 influences processes like cell migration, proliferation, and survival. Additionally, clustering of Integrin β1 upon ligand binding activates intracellular signaling pathways that are vital for cellular responses to the extracellular environment. Anti-Integrin β1 antibody (102DF5) enables researchers to gain insights into the dynamics of cell adhesion and the signaling mechanisms that underlie various physiological and pathological processes.

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Integrin β1/ITGB1 Antibody (102DF5) References:

1. SHARPIN is an endogenous inhibitor of β1-integrin activation.  |  Rantala, JK., et al. 2011. Nat Cell Biol. 13: 1315-24. PMID: 21947080
2. The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma.  |  Wang, D., et al. 2012. Clin Cancer Res. 18: 4589-99. PMID: 22829201
3. Integrin Beta 1 suppresses multilayering of a simple epithelium.  |  Chen, J. and Krasnow, MA. 2012. PLoS One. 7: e52886. PMID: 23285215
4. Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.  |  Liu, W., et al. 2013. Mol Cell. 49: 719-29. PMID: 23317506
5. Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration.  |  Rankin, CR., et al. 2013. J Biol Chem. 288: 15229-39. PMID: 23558678
6. Renin-Expressing Cells Require β1-Integrin for Survival and for Development and Maintenance of the Renal Vasculature.  |  Mohamed, TH., et al. 2020. Hypertension. 76: 458-467. PMID: 32594804
7. β1 Integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs.  |  Guo, SS., et al. 2020. Development. 147: PMID: 33051257
8. Role of β1-integrin in promoting cell motility and tamoxifen resistance of human breast cancer MCF-7 cells.  |  Hu, S., et al. 2023. Asia Pac J Clin Oncol. 19: e223-e230. PMID: 36065151
9. Fertilization, but Not Post-Implantation Development, Can Occur in the Absence of Sperm and Oocyte Beta1 Integrin in Mice.  |  Mimouni, NEH., et al. 2022. Int J Mol Sci. 23: PMID: 36430291
10. Astrocyte-associated fibronectin promotes the proinflammatory phenotype of astrocytes through β1 integrin activation.  |  Chu, PH., et al. 2023. Mol Cell Neurosci. 125: 103848. PMID: 36948232

The preferred Integrin β1/ITGB1 antibody is Integrin β1/ITGB1 Antibody (K-20): sc-18887.