Integrin αX/ITGAX/CD11c Antibody (2Q862): sc-71454

Integrin αX Antibody (2Q862) is a mouse monoclonal IgG antibody that detects Integrin αX in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Integrin αX is a type 1 transmembrane protein that plays a crucial role in the immune response by forming a leukocyte-specific integrin when combined with the β2 chain, known as the inactivated-C3b receptor 4 (CR4). Anti-Integrin αX antibody (2Q862) is essential for mediating the adherence of neutrophils and monocytes to activated endothelial cells, as well as facilitating the phagocytosis of complement-coated particles, which is vital for clearing pathogens and debris from the body. Notably, abnormal expression of Integrin αX is associated with hairy cell leukemia, highlighting its importance in cancer biology and immune regulation. The transcription of Integrin αX is influenced by various proteins and DNA elements, including Sp1, AP-1 family members, and PU.1, which underscores the complexity of its regulation and the potential for targeted therapeutic strategies. Integrin αX is predominantly found on monocyte-derived dendritic cells, macrophages, and natural killer cells, and upon activation, dendritic cells, particularly Langerhans cells located in the skin and mucosal tissues, migrate to lymphoid organs to interact with T and B cells, thereby initiating and shaping adaptive immune responses. Integrin αX monoclonal antibody (2Q862) is an invaluable tool for researchers studying immune cell interactions and the underlying mechanisms of immune-related diseases.

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Integrin αX/ITGAX/CD11c Antibody (2Q862) References:

1. CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin.  |  Männ, L., et al. 2016. Eur J Immunol. 46: 2028-42. PMID: 27184067
2. Activated Human Memory B Lymphocytes Use CR4 (CD11c/CD18) for Adhesion, Migration, and Proliferation.  |  Nagy-Baló, Z., et al. 2020. Front Immunol. 11: 565458. PMID: 33133077
3. HIV-1-Specific CD11c+ CD8+ T Cells Display Low PD-1 Expression and Strong Anti-HIV-1 Activity.  |  Guo, AL., et al. 2021. Front Immunol. 12: 757457. PMID: 34721433
4. Reduction in CD11c+ microglia correlates with clinical progression in chronic experimental autoimmune demyelination.  |  Mayrhofer, F., et al. 2021. Neurobiol Dis. 161: 105556. PMID: 34752925
5. Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands.  |  Lu, L., et al. 2022. Sci Rep. 12: 931. PMID: 35042931
6. Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23.  |  Galle-Treger, L., et al. 2022. Nat Commun. 13: 1440. PMID: 35301333
7. Decreased granzyme-B expression in CD11c+CD8+ T cells associated with disease progression in patients with HBV-related hepatocellular carcinoma.  |  Gao, L., et al. 2023. Front Immunol. 14: 1107483. PMID: 36798119
8. Topical Diacerein Decreases Skin and Splenic CD11c+ Dendritic Cells in Psoriasis.  |  Brunner, SM., et al. 2023. Int J Mol Sci. 24: PMID: 36901755
9. Rab8a restores diverse innate functions in CD11c+CD11b+ dendritic cells from aged mice.  |  Singh, S., et al. 2024. Nat Commun. 15: 10300. PMID: 39604443
10. The leukocyte integrin gene CD11c is transcriptionally regulated during monocyte differentiation.  |  Noti, JD. and Reinemann, BC. 1995. Mol Immunol. 32: 361-9. PMID: 7739574

The preferred Integrin αX/ITGAX/CD11c antibody is Integrin αX/ITGAX/CD11c Antibody (B-6): sc-46676.