Integrin αM/CD11b Antibody (CBRM1/5): sc-23934

Integrin αM Antibody (CBRM1/5) is a mouse monoclonal IgG1 kappa antibody engineered to recognize the Integrin αM protein, also known by alternative names such as CD11b, ITGAM, Mac-1 α subunit, complement component receptor-3 α (CR3α), MAC1A, MO1A, and macrophage antigen a polypeptide. Integrin αM monoclonal antibody (CBRM1/5) is raised against immunoaffinity-purified human Integrin αM (Mac-1) and demonstrates excellent reactivity with the human Integrin αM protein in applications including immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin αM is a crucial heterodimeric cell adhesion molecule composed of an αM chain paired with a β2 chain, forming the leukocyte-specific integrin Mac-1 (CR3). The structural integrity of Integrin αM facilitates interactions with key proteins such as intracellular adhesion molecules (ICAM-1 and ICAM-2), iC3b, fibrinogen (though not a major ligand in all contexts), and VCAM-1, which are essential for mediating immune cell adhesion, migration, and phagocytosis. These interactions play a vital role in the adherence of neutrophils and monocytes to activated endothelial cells and the clearance of complement-coated pathogens, highlighting the importance of Integrin αM in immune responses. By targeting these interaction domains, anti-Integrin αM antibody (CBRM1/5) ensures precise detection and analysis of Integrin αM, supporting advanced research in immunology and inflammatory processes. Available for use in a variety of experimental setups, Integrin αM (CBRM1/5) antibody is an indispensable tool for scientists investigating the mechanisms of leukocyte function and immune regulation.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.