Integrin αM/CD11b Antibody (CBRM1/5): sc-23934

Integrin αM Antibody (CBRM1/5) is a mouse monoclonal IgG1 kappa antibody engineered to recognize the Integrin αM protein, also known by alternative names such as CD11b, ITGAM, Mac-1 α subunit, complement component receptor-3 α (CR3α), MAC1A, MO1A, and macrophage antigen a polypeptide. Integrin αM monoclonal antibody (CBRM1/5) is raised against immunoaffinity-purified human Integrin αM (Mac-1) and demonstrates excellent reactivity with the human Integrin αM protein in applications including immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin αM is a crucial heterodimeric cell adhesion molecule composed of an αM chain paired with a β2 chain, forming the leukocyte-specific integrin Mac-1 (CR3). The structural integrity of Integrin αM facilitates interactions with key proteins such as intracellular adhesion molecules (ICAM-1 and ICAM-2), iC3b, fibrinogen (though not a major ligand in all contexts), and VCAM-1, which are essential for mediating immune cell adhesion, migration, and phagocytosis. These interactions play a vital role in the adherence of neutrophils and monocytes to activated endothelial cells and the clearance of complement-coated pathogens, highlighting the importance of Integrin αM in immune responses. By targeting these interaction domains, anti-Integrin αM antibody (CBRM1/5) ensures precise detection and analysis of Integrin αM, supporting advanced research in immunology and inflammatory processes. Available for use in a variety of experimental setups, Integrin αM (CBRM1/5) antibody is an indispensable tool for scientists investigating the mechanisms of leukocyte function and immune regulation.

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Integrin αM/CD11b Antibody (CBRM1/5) References:

1. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation.  |  van Spriel, AB., et al. 2001. Blood. 97: 2478-86. PMID: 11290613
2. Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms.  |  Hoefer, IE., et al. 2004. Circ Res. 94: 1179-85. PMID: 15059933
3. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).  |  Han, S., et al. 2009. Hum Mol Genet. 18: 1171-80. PMID: 19129174
4. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury.  |  Hirahashi, J., et al. 2009. Circulation. 120: 1255-65. PMID: 19752320
5. The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.  |  Rhodes, B., et al. 2012. Ann Rheum Dis. 71: 2028-34. PMID: 22586164
6. The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis.  |  Zhang, X., et al. 2016. Biochim Biophys Acta. 1864: 471-8. PMID: 26876535
7. Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.  |  Avery, JT., et al. 2019. Mamm Genome. 30: 245-259. PMID: 31673770
8. CD11b is a novel alternate receptor for CD154 during alloimmunity.  |  Liu, D. and Ford, ML. 2020. Am J Transplant. 20: 2216-2225. PMID: 32149455
9. Murine Macrophage Requires CD11b to Recognize Talaromyces marneffei.  |  Hu, Y., et al. 2020. Infect Drug Resist. 13: 911-920. PMID: 32273736
10. Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils.  |  Graham, IL., et al. 1994. J Cell Biol. 127: 1139-47. PMID: 7525604

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.