Integrin α5/ITGA5/CD49e Antibody (MFR5/5H10): sc-23941

Integrin α5 Antibody (MFR5/5H10) is a rat monoclonal IgG2a antibody that detects Integrin α5 in mouse, rat, and human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Integrin α5 is a crucial component of the integrin family, functioning primarily as a receptor for fibronectin, a key extracellular matrix protein. This interaction is vital for various cellular processes, including adhesion, migration, and differentiation, as it facilitates communication between cells and their surrounding environment. Anti-Integrin α5 antibody (MFR5/5H10) enables detection of cell surface Integrin α5, which allows cells to respond to fibronectin, promoting cell attachment and spreading - essential processes during tissue development and repair. Integrin α5 plays a significant role in signaling pathways that regulate cell behavior, influencing processes such as wound healing and immune responses. Integrin α5 monoclonal antibody (MFR5/5H10) helps researchers gain insights into cell adhesion dynamics and underlying mechanisms of various physiological and pathological conditions, making this antibody an invaluable tool in cell biology and tissue engineering studies.

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Integrin α5/ITGA5/CD49e Antibody (MFR5/5H10) References:

1. KGF promotes integrin alpha5 expression through CCAAT/enhancer-binding protein-beta.  |  Koria, P. and Andreadis, ST. 2007. Am J Physiol Cell Physiol. 293: C1020-31. PMID: 17596295
2. Integrin-alpha5 mediates epidermal growth factor-induced retinal pigment epithelial cell proliferation and migration.  |  Chen, Z., et al. 2010. Pathobiology. 77: 88-95. PMID: 20332668
3. AKR1B10 promotes breast cancer metastasis through integrin α5/δ-catenin mediated FAK/Src/Rac1 signaling pathway.  |  Huang, C., et al. 2016. Oncotarget. 7: 43779-43791. PMID: 27248472
4. Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling.  |  Yun, S., et al. 2016. Nat Cell Biol. 18: 1043-53. PMID: 27595237
5. Integrin α5/ITGA5 Promotes The Proliferation, Migration, Invasion And Progression Of Oral Squamous Carcinoma By Epithelial-Mesenchymal Transition.  |  Deng, Y., et al. 2019. Cancer Manag Res. 11: 9609-9620. PMID: 32009816
6. Integrin α5 mediates intrinsic cisplatin resistance in three-dimensional nasopharyngeal carcinoma spheroids via the inhibition of phosphorylated ERK /caspase-3 induced apoptosis.  |  Ngaokrajang, U., et al. 2021. Exp Cell Res. 406: 112765. PMID: 34358523
7. Fibronectin and Integrin α5 play overlapping and independent roles in regulating the development of pharyngeal endoderm and cartilage.  |  Gao, Y., et al. 2022. Dev Biol. 489: 122-133. PMID: 35732225
8. Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5.  |  Zhao, D., et al. 2022. Bone Res. 10: 49. PMID: 35851577
9. Inhibition of bladder cancer growth with homoharringtonine by inactivating integrin α5/β1-FAK/Src axis: A novel strategy for drug application.  |  Wu, Q., et al. 2023. Pharmacol Res. 188: 106654. PMID: 36640858
10. Astaxanthin inhibits integrin α5 expression by suppressing activation of JAK1/STAT3 in Helicobacter pylori‑stimulated gastric epithelial cells.  |  Woo, J., et al. 2023. Mol Med Rep. 27: PMID: 37203390

The preferred Integrin α5/ITGA5/CD49e antibody is Integrin α5/ITGA5/CD49e Antibody (P1D6): sc-13547.