Integrin α5/ITGA5/CD49e Antibody (1): sc-136224
- Integrin α5/ITGA5/CD49e Antibody (1) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 853-1002 of Integrin α5 of human origin
- recommended for detection of Integrin α5 of human origin by WB, IP and IF
- See Integrin α5/ITGA5/CD49e (C-9): sc-376199 for Integrin α5/ITGA5/CD49e antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin α5/ITGA5/CD49e Antibody (1). This work is in progress.
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Integrin α5 Antibody (1) is a mouse monoclonal IgG2a light chain antibody that detects Integrin α5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Integrin α5 antibody (1) plays a crucial role in cell adhesion and is primarily located on the cell surface, where Integrin α5 forms a heterodimer with the β1 subunit to create the α5β1 integrin receptor. This receptor is essential for binding to extracellular matrix components like fibronectin, which is vital for various cellular processes, including tissue repair and development. The interaction between Integrin α5 and fibronectin not only facilitates cell attachment but also triggers intracellular signaling pathways that influence cell behavior, such as migration and proliferation. By understanding the localization and function of Integrin α5, researchers can gain insights into its involvement in pathological conditions, including cancer metastasis and wound healing. Integrin α5 monoclonal antibody (1) is an invaluable tool for studying these processes and advancing our knowledge of integrin biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Integrin α5/ITGA5/CD49e Antibody (1) References:
- Signaling for integrin alpha5/beta1 expression in Helicobacter pylori-infected gastric epithelial AGS cells. | Cho, SO., et al. 2006. Ann N Y Acad Sci. 1090: 298-304. PMID: 17384273
- JNK mediates insulin-like growth factor binding protein 2/integrin alpha5-dependent glioma cell migration. | Mendes, KN., et al. 2010. Int J Oncol. 37: 143-53. PMID: 20514406
- ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression. | Nam, EH., et al. 2014. Carcinogenesis. 35: 302-14. PMID: 24130169
- Integrin α5 triggers the metastatic potential in renal cell carcinoma. | Breuksch, I., et al. 2017. Oncotarget. 8: 107530-107542. PMID: 29296184
- Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis. | Budatha, M., et al. 2018. J Am Heart Assoc. 7: PMID: 29382667
- Extracellular matrix stiffness controls osteogenic differentiation of mesenchymal stem cells mediated by integrin α5. | Sun, M., et al. 2018. Stem Cell Res Ther. 9: 52. PMID: 29490668
- TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin α5 pathway. | Zhao, D., et al. 2020. Mol Med. 26: 27. PMID: 32248791
- Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway. | Wang, X., et al. 2020. J Exp Clin Cancer Res. 39: 221. PMID: 33081836
- Integrin α5 promotes migration and invasion through the FAK/STAT3/AKT signaling pathway in icotinib-resistant non-small cell lung cancer cells. | Yang, Y., et al. 2021. Oncol Lett. 22: 556. PMID: 34084223
- Millettocalyxin B Inhibits Migratory Behavior of Lung Cancer Cells via Integrin α5 Suppression. | Lafauy, P., et al. 2021. Anticancer Res. 41: 3843-3849. PMID: 34281844
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin α5/ITGA5/CD49e Antibody (1) | sc-136224 | 50 µg/0.5 ml | $322.00 |