Integrin α4/ITGA4/CD49d Antibody (C-2): sc-365569

Integrin α4 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin α4 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Integrin α4 antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin α4 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Integrin α4 expression on the cell surface is vital for mediating cell adhesion to the extracellular matrix and facilitating interactions with other cells, particularly through binding to ligands such as fibronectin and intracellular adhesion molecules (ICAMs). This interaction is essential for various physiological processes, including immune response, tissue repair, and inflammation. Integrin α4 plays a significant role in signaling pathways that influence cell growth, differentiation, and migration, making Integrin α4 a key player in both normal physiological functions and pathological conditions, such as cancer metastasis and autoimmune diseases. Integrin α4 monoclonal antibody (C-2) effectively detects across multiple applications, making this reagent an invaluable tool for researchers studying cell adhesion and signaling mechanisms in human tissues.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin α4/ITGA4/CD49d Antibody (C-2) References:

1. Aberrant methylation of integrin alpha4 gene in human gastric cancer cells.  |  Park, J., et al. 2004. Oncogene. 23: 3474-80. PMID: 14990990
2. NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation.  |  Joo, NE., et al. 2008. Cell Death Differ. 15: 899-907. PMID: 18292781
3. DcR3 protects THP-1 macrophages from apoptosis by increasing integrin alpha4.  |  Tateishi, K., et al. 2009. Biochem Biophys Res Commun. 389: 593-8. PMID: 19748482
4. Integrin α4 impacts on differential adhesion of preadipocytes and stem cells on synthetic polymers.  |  Hoss, M., et al. 2013. J Tissue Eng Regen Med. 7: 312-23. PMID: 22318983
5. NMR structure of integrin α4 cytosolic tail and its interactions with paxillin.  |  Chua, GL., et al. 2013. PLoS One. 8: e55184. PMID: 23383101
6. The hydrophobic contacts between the center of the βI domain and the α1/α7 helices are crucial for the low-affinity state of integrin α4 β7.  |  Liu, J., et al. 2014. FEBS J. 281: 2915-26. PMID: 24802248
7. Antitumor effect of the integrin α4 signaling inhibitor JK273 in non-small cell lung cancer NCI-H460 cells.  |  Lu, TN., et al. 2017. Biochem Biophys Res Commun. 491: 355-360. PMID: 28728840
8. Integrin α4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection.  |  Cui, LL., et al. 2017. Stroke. 48: 2895-2900. PMID: 28916665
9. A PSCA/PGRN-NF-κB-Integrin-α4 Axis Promotes Prostate Cancer Cell Adhesion to Bone Marrow Endothelium and Enhances Metastatic Potential.  |  Zhao, Z., et al. 2020. Mol Cancer Res. 18: 501-513. PMID: 31722969
10. Integrin α4 up-regulation activates the hedgehog pathway to promote arsenic and benzo[α]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis.  |  Xie, J., et al. 2020. Cancer Lett. 493: 143-155. PMID: 32860851

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α4/ITGA4/CD49d Antibody (C-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α4/ITGA4/CD49d Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α4/ITGA4/CD49d Antibody (C-2) Specifications

Alternate Product Name: Integrin α4

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 796-1005

Epitope Target: Integrin α4

Epitope Species: human

Product Reactivity/Detection: Integrin α4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Integrin α4/ITGA4/CD49d Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin α4/ITGA4/CD49d antibody is Integrin α4/ITGA4/CD49d Antibody (A-7): sc-365209.