Integrin α2/ITGA2/CD49b Antibody (P1H5): sc-13546

Integrin α2 Antibody (P1H5) is a mouse monoclonal IgG2b antibody that detects Integrin α2 in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α2 plays a crucial role in mediating cell adhesion to collagen, which is essential for maintaining tissue integrity and facilitating cellular communication within the extracellular matrix. Integrin α2 is primarily located on the surface of platelets and various other cell types, where anti-Integrin α2 antibody (P1H5) detects interactions with collagen fibers, promoting platelet aggregation and wound healing processes. Integrin α2′s ability to bind collagen not only aids in cell adhesion but also initiates intracellular signaling pathways that influence cell behavior, including migration and survival. Furthermore, regulation of Integrin α2 expression is vital for proper tissue remodeling and repair, making Integrin α2 (P1H5) antibody a significant tool for therapeutic interventions in conditions such as cardiovascular diseases and fibrosis. Anti-Integrin α2 antibody (P1H5) serves as an invaluable tool for researchers studying the dynamics of cell adhesion and the intricate signaling mechanisms that govern cellular responses in health and disease.

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Integrin α2/ITGA2/CD49b Antibody (P1H5) References:

1. Regulation and functions of integrin α2 in cell adhesion and disease.  |  Adorno-Cruz, V. and Liu, H. 2019. Genes Dis. 6: 16-24. PMID: 30906828
2. Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells.  |  Lee, HM., et al. 2020. Stem Cell Res Ther. 11: 210. PMID: 32493499
3. Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival.  |  Huang, YL., et al. 2021. iScience. 24: 103168. PMID: 34646995
4. Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling.  |  Liu, X., et al. 2022. Invest Ophthalmol Vis Sci. 63: 13. PMID: 35006271
5. Integrin α2 and β1 Cross-Communication with mTOR/AKT and the CDK-Cyclin Axis in Hepatocellular Carcinoma Cells.  |  Juratli, MA., et al. 2022. Cancers (Basel). 14: PMID: 35626034
6. Targeting integrin α2 as potential strategy for radiochemosensitization of glioblastoma.  |  Korovina, I., et al. 2023. Neuro Oncol. 25: 648-661. PMID: 36219689
7. Role of integrin α2 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells.  |  Kawami, M., et al. 2022. Toxicol Res. 38: 449-458. PMID: 36277370
8. Integrin α2 promotes immune escape in non-small-cell lung cancer by enhancing PD-L1 expression in exosomes to inhibit CD8 + T-cell activity.  |  Jing, H., et al. 2024. J Investig Med. 72: 57-66. PMID: 37804164
9. Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis.  |  Brockhaus, K., et al. 2024. Front Cell Dev Biol. 12: 1448725. PMID: 39220682
10. Integrin α2 in the microenvironment and the tumor compartment of digestive (gastrointestinal) cancers: emerging regulators and therapeutic opportunities.  |  Liu, T., et al. 2024. Front Oncol. 14: 1439709. PMID: 39568561

The preferred Integrin α2/ITGA2/CD49b antibody is Integrin α2/ITGA2/CD49b Antibody (C-9): sc-74466.