Integrin α2/ITGA2/CD49b Antibody (P1E6): sc-53502

Integrin α2 Antibody (P1E6) is a mouse monoclonal IgG1 antibody that detects Integrin α2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Integrin α2 plays a crucial role in mediating cell adhesion to collagen, which is essential for maintaining tissue integrity and facilitating communication between cells and the extracellular matrix. Integrin α2 is primarily located on the surface of platelets and various other cell types, where anti-Integrin α2 antibody (P1E6) can detect interactions with collagen fibers, promoting platelet aggregation and wound healing. The ability of Integrin α2 to bind collagen is vital for the formation of stable blood clots and the repair of damaged tissues, highlighting its importance in both hemostasis and tissue regeneration. Furthermore, Integrin α2 is involved in signaling pathways that regulate cell migration and proliferation, making Integrin α2 a key player in various physiological and pathological processes, including inflammation and cancer metastasis. Integrin α2 monoclonal antibody (P1E6) is an invaluable tool for researchers studying these critical biological functions and the underlying mechanisms of diseases associated with integrin dysregulation.

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Integrin α2/ITGA2/CD49b Antibody (P1E6) References:

1. Human granulosa cells express integrin alpha2 and collagen type IV: possible involvement of collagen type IV in granulosa cell luteinization.  |  Yamada, S., et al. 1999. Mol Hum Reprod. 5: 607-17. PMID: 10381815
2. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium.  |  Funahashi, Y., et al. 2002. Cancer Res. 62: 6116-23. PMID: 12414636
3. Activated epidermal growth factor receptor induces integrin alpha2 internalization via caveolae/raft-dependent endocytic pathway.  |  Ning, Y., et al. 2007. J Biol Chem. 282: 6380-7. PMID: 17179151
4. Reorganization of the integrin alpha2 subunit controls cell adhesion and cancer cell invasion in prostate cancer.  |  Van Slambrouck, S., et al. 2009. Int J Oncol. 34: 1717-26. PMID: 19424590
5. Expression of integrin α2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2Rγ(c) null mice.  |  Wong, WM., et al. 2013. Stem Cells. 31: 360-71. PMID: 23165626
6. An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens.  |  Carafoli, F., et al. 2013. PLoS One. 8: e69833. PMID: 23922814
7. The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium.  |  Ahmadi, A., et al. 2014. Biomaterials. 35: 4749-58. PMID: 24631247
8. Induction of integrin α2 in a highly bone metastatic human prostate cancer cell line: roles of RANKL and AR under three-dimensional suspension culture.  |  Ziaee, S. and Chung, LW. 2014. Mol Cancer. 13: 208. PMID: 25200184
9. A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling.  |  Xu, J., et al. 1998. J Cell Biol. 140: 709-19. PMID: 9456329
10. Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequence.  |  Knight, CG., et al. 1998. J Biol Chem. 273: 33287-94. PMID: 9837901

The preferred Integrin α2/ITGA2/CD49b antibody is Integrin α2/ITGA2/CD49b Antibody (C-9): sc-74466.