Integrin α2/ITGA2/CD49b Antibody (244G1): sc-47770
- Integrin α2/ITGA2/CD49b Antibody (244G1) is a mouse monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant Integrin α2 of human origin
- recommended for detection of Integrin α2 of human origin by WB, IP, IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin α2/ITGA2/CD49b Antibody (244G1). This work is in progress.
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Integrin α2 Antibody (244G1) is a mouse monoclonal IgG1 antibody that detects Integrin α2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α2 plays a crucial role in mediating cell adhesion to collagen, which is essential for maintaining tissue integrity and facilitating communication between cells and the extracellular matrix. Integrin α2 is primarily located on the surface of platelets and various other cell types, where anti-Integrin α2 antibody (244G1) detects interactions with collagen fibers, promoting platelet aggregation and wound healing. Integrin α2′s ability to bind collagen is vital for the formation of stable blood clots and the repair of damaged tissues, highlighting Integrin α2′s importance in both hemostasis and tissue regeneration. Furthermore, Integrin α2 is involved in signaling pathways that regulate cell migration and differentiation, making Integrin α2 a key player in various physiological and pathological processes, including inflammation and cancer metastasis. Integrin α2 (244G1) antibody is an invaluable tool for researchers studying these critical biological functions and the underlying mechanisms of diseases associated with integrin dysregulation.
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Integrin α2/ITGA2/CD49b Antibody (244G1) References:
- Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2. | Choi, S., et al. 2009. Biochem Biophys Res Commun. 384: 231-5. PMID: 19394307
- Integrin alpha2 mediates selective metastasis to the liver. | Yoshimura, K., et al. 2009. Cancer Res. 69: 7320-8. PMID: 19738067
- Expression of laminin β1 and integrin α2 in the anterior temporal neocortex tissue of patients with intractable epilepsy. | Wu, Y., et al. 2011. Int J Neurosci. 121: 323-8. PMID: 21370991
- Involvement of host cell integrin α2 in Cryptosporidium parvum infection. | Zhang, H., et al. 2012. Infect Immun. 80: 1753-8. PMID: 22354032
- Caveolin-1 up-regulates integrin α2,6-sialylation to promote integrin α5β1-dependent hepatocarcinoma cell adhesion. | Yu, S., et al. 2013. FEBS Lett. 587: 782-7. PMID: 23416306
- PRL-3 suppresses c-Fos and integrin α2 expression in ovarian cancer cells. | Liu, H., et al. 2013. BMC Cancer. 13: 80. PMID: 23418787
- A novel Lin-CD34+CD38- integrin α2- bipotential megakaryocyte-erythrocyte progenitor population in the human bone marrow. | Wong, WM., et al. 2016. Leukemia. 30: 1399-402. PMID: 26500141
- Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta. | Lee, CQE., et al. 2018. Development. 145: PMID: 29540503
- Hierarchical Micro-Nano Topography Promotes Cell Adhesion and Osteogenic Differentiation via Integrin α2-PI3K-AKT Signaling Axis. | Zheng, H., et al. 2020. Front Bioeng Biotechnol. 8: 463. PMID: 32509748
- The small-molecule protein ligand interface stabiliser E7820 induces differential cell line specific responses of integrin α2 expression. | Hülskamp, MD., et al. 2021. BMC Cancer. 21: 571. PMID: 34006252
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin α2/ITGA2/CD49b Antibody (244G1) | sc-47770 | 200 µg/ml | $322.00 |