INSR/Insulin Receptor α Antibody (MA-20): sc-57344
- INSR/Insulin Receptor α Antibody (MA-20) is a mouse monoclonal IgG2b κ, cited in 14 publications, provided at 200 µg/ml
- raised against placental insulin Rα of human oirgin
- recommended for detection of insulin Rα of mouse, rat and human origin by WB and IP
- Anti-INSR/Insulin Receptor α Antibody (MA-20) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for INSR/Insulin Receptor α Antibody (MA-20). This work is in progress.
QUICK LINKS
Insulin Rα Antibody (MA-20) is a mouse monoclonal IgG2b kappa light chain antibody specifically engineered to target the insulin receptor alpha subunit (Insulin Rα) of human origin in immunoprecipitation (IP) applications. Insulin Rα monoclonal antibody (MA-20) is raised against placental human Insulin Rα, enabling precise detection of the insulin receptor in human samples, and cross-reacts with Insulin Rα from mouse and rat species, providing versatility for studies involving these model organisms. The insulin receptor is a critical heterodimeric protein composed of two extracellular alpha subunits and two transmembrane beta subunits connected by disulfide bonds. The alpha subunits are responsible for insulin binding, which triggers a series of intracellular signaling pathways that regulate glucose uptake, glycogen synthesis, and overall cellular metabolism. Post-translational modifications of Insulin Rα, particularly N-linked glycosylation, are essential for proper protein folding, stability, and cell surface localization. These glycosylation events facilitate the correct assembly and dimerization of the receptor. Additionally, glycosylation influences the receptor′s interaction with other cellular proteins and insulin responsiveness, playing a pivotal role in maintaining metabolic homeostasis. Dysregulation of these post-translational modifications can lead to impaired insulin signaling, contributing to the development of insulin resistance and type 2 diabetes mellitus. Insulin Rα (MA-20) monoclonal antibody is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, allowing for flexible use in diverse experimental setups. Anti-Insulin Rα antibody (MA-20) is recommended for researchers investigating the molecular underpinnings of insulin action and the pathophysiology of diabetes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INSR/Insulin Receptor α Antibody (MA-20) | sc-57344 | 200 µg/ml | $322.00 | |||
INSR/Insulin Receptor α Antibody (MA-20): m-IgG Fc BP-HRP Bundle | sc-551776 | 200 µg Ab; 10 µg BP | $361.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) AC | sc-57344 AC | 500 µg/ml, 25% agarose | $424.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) HRP | sc-57344 HRP | 200 µg/ml | $322.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) FITC | sc-57344 FITC | 200 µg/ml | $336.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) PE | sc-57344 PE | 200 µg/ml | $349.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) Alexa Fluor® 488 | sc-57344 AF488 | 200 µg/ml | $364.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) Alexa Fluor® 546 | sc-57344 AF546 | 200 µg/ml | $364.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) Alexa Fluor® 594 | sc-57344 AF594 | 200 µg/ml | $364.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) Alexa Fluor® 647 | sc-57344 AF647 | 200 µg/ml | $364.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) Alexa Fluor® 680 | sc-57344 AF680 | 200 µg/ml | $364.00 | |||
INSR/Insulin Receptor α Antibody (MA-20) Alexa Fluor® 790 | sc-57344 AF790 | 200 µg/ml | $364.00 |