Inhibin β-B Antibody (H-8): sc-376971

Inhibin β-B Antibody (H-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects Inhibin beta-B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Inhibin beta-B antibody (H-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Inhibin beta-B protein plays a crucial role in regulating reproductive hormones, particularly by inhibiting follicle-stimulating hormone secretion from the pituitary gland, which is essential for normal reproductive function and fertility. This regulation helps maintain the hormone balance necessary for processes such as germ cell development and maturation, as well as overall reproductive health. Inhibin beta-B is predominantly expressed in the liver, uterus, and ovaries, with expression levels varying significantly during different physiological states, such as pregnancy or hormonal treatments. The balance between inhibins and activins, which have opposing functions, underscores Inhibin beta-B′s importance in the broader context of the TGFβ superfamily, which is involved in various developmental and homeostatic processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Inhibin β-B Antibody (H-8) References:

1. Pachytene spermatocytes in co-culture inhibit rat Sertoli cell synthesis of inhibin beta B-subunit and inhibin B but not the inhibin alpha-subunit.  |  Clifton, RJ., et al. 2002. J Endocrinol. 172: 565-74. PMID: 11874705
2. Activation of the bone morphogenetic protein signaling pathway induces inhibin beta(B)-subunit mRNA and secreted inhibin B levels in cultured human granulosa-luteal cells.  |  Jaatinen, R., et al. 2002. J Clin Endocrinol Metab. 87: 1254-61. PMID: 11889196
3. Sexually dimorphic regulation of inhibin beta B in establishing gonadal vasculature in mice.  |  Yao, HH., et al. 2006. Biol Reprod. 74: 978-83. PMID: 16452457
4. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
5. Multiple type-beta transforming growth factors and their receptors.  |  Massagué, J., et al. 1987. J Cell Physiol Suppl. Suppl 5: 43-7. PMID: 2890647
6. Inhibin A-subunit cDNAs from porcine ovary and human placenta.  |  Mayo, KE., et al. 1986. Proc Natl Acad Sci U S A. 83: 5849-53. PMID: 3016724
7. Human inhibin genes. Genomic characterisation and sequencing.  |  Stewart, AG., et al. 1986. FEBS Lett. 206: 329-34. PMID: 3758355
8. Evaluation of the prognostic and therapeutic potential of inhibin beta B for oral squamous cell carcinoma.  |  Chung, YY., et al. 2024. J Dent Sci. 19: 448-454. PMID: 38303818
9. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.  |  Vassalli, A., et al. 1994. Genes Dev. 8: 414-27. PMID: 8125256
10. Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation.  |  Albano, RM., et al. 1993. Development. 117: 711-23. PMID: 8330535
11. Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.  |  Schmitt, J., et al. 1996. Genomics. 32: 358-66. PMID: 8838799
12. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Inhibin β-B Antibody (H-8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Inhibin β-B Antibody (H-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Inhibin β-B Antibody (H-8) Specifications

Alternate Product Name: INHBB

Product Clone Name: H-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 298-407

Epitope Target: Inhibin β-B

Epitope Species: human

Product Reactivity/Detection: Inhibin β-B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Inhibin β-B Antibody (H-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Inhibin β-A antibody is Inhibin β-A Antibody (E-1): sc-166503.