Influenza B NP Antibody (B017): sc-57885

Influenza B NP Antibody (B017) is a mouse monoclonal IgG2b antibody that detects the nucleoprotein (NP) of Influenza B virus by western blotting (WB) and immunofluorescence (IF). Anti-Influenza B NP antibody (B017) is available in a non-conjugated form, specifically designed for researchers studying the Influenza B virus. The nucleoprotein plays a crucial role in the viral life cycle, as it is essential for the encapsidation of viral RNA and the formation of viral ribonucleoprotein complexes, which are vital for the transcription and replication of the viral genome. Understanding the function of the nucleoprotein is important because this protein not only aids in the assembly of new virions but also serves as a target for the host immune response, making nucleoprotein a key player in the pathogenesis of Influenza B. Post-translational modifications of nucleoprotein, such as phosphorylation, can influence viral interaction with host cell machinery and impact virulence and immune evasion. Using Influenza B NP (B017) monoclonal antibody in research can provide insights into the mechanisms of Influenza B virus infection and contribute to the development of effective therapeutic strategies.

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Influenza B NP Antibody (B017) References:

1. Preferential phosphorylation of NP-protein of influenza A2 virus by virion-associated protein kinase.  |  Sugiyama, K., et al. 1976. Jpn J Microbiol. 20: 227-32. PMID: 184330
2. The C-terminal end of parainfluenza virus 5 NP protein is important for virus-like particle production and M-NP protein interaction.  |  Schmitt, PT., et al. 2010. J Virol. 84: 12810-23. PMID: 20943976
3. Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein.  |  Ng, AK., et al. 2012. J Virol. 86: 6758-67. PMID: 22496219
4. Inhibition of influenza A virus replication by influenza B virus nucleoprotein: an insight into interference between influenza A and B viruses.  |  Wanitchang, A., et al. 2012. Virology. 432: 194-203. PMID: 22770925
5. Nuclear import of influenza B virus nucleoprotein: involvement of an N-terminal nuclear localization signal and a cleavage-protection motif.  |  Wanitchang, A., et al. 2013. Virology. 443: 59-68. PMID: 23689061
6. The N terminus of the influenza B virus nucleoprotein is essential for virus viability, nuclear localization, and optimal transcription and replication of the viral genome.  |  Sherry, L., et al. 2014. J Virol. 88: 12326-38. PMID: 25122787
7. Residues 41V and/or 210D in the NP protein enhance polymerase activities and potential replication of novel influenza (H7N9) viruses at low temperature.  |  Zhu, W., et al. 2015. Virol J. 12: 71. PMID: 25940512
8. Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E.  |  Zhan, Y., et al. 2020. PLoS Pathog. 16: e1008610. PMID: 32603377
9. The Sendai virus V protein interacts with the NP protein to regulate viral genome RNA replication.  |  Horikami, SM., et al. 1996. Virology. 222: 383-90. PMID: 8806522
10. The N-terminal extension of the influenza B virus nucleoprotein is not required for nuclear accumulation or the expression and replication of a model RNA.  |  Stevens, MP. and Barclay, WS. 1998. J Virol. 72: 5307-12. PMID: 9573310

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Influenza B NP Antibody (B017) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Influenza B NP Antibody (B017) Specifications

Alternate Product Name: Influenza B NP

Product Clone Name: B017

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Influenza B NP

Epitope Species: Influenza B virus

Product Reactivity/Detection: nucleoprotein (NP)

Species Reactivity/Detection: Influenza B virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Influenza B NP Antibody (B017): N/A