Influenza B NP Antibody (3E9/B2): sc-57513

Influenza B NP Antibody (3E9/B2) is a mouse monoclonal IgG2a antibody that detects Influenza B NP by western blotting (WB) and immunofluorescence (IF). Influenza B NP, or nucleoprotein, plays a crucial role in the viral life cycle as it encapsidates the viral RNA genome, forming ribonucleoprotein complexes essential for viral replication and transcription. Anti-Influenza B NP antibody (3E9/B2) recognizes a protein primarily located in the nucleus of infected cells, where Influenza B NP facilitates the transport of viral RNA to the cytoplasm for protein synthesis and assembly of new virions. Influenza B NP′s ability to interact with various host cell factors is vital for the virus′s ability to hijack the host′s cellular machinery, making Influenza B NP a key target for therapeutic interventions and vaccine development. Anti-Influenza B NP antibody (3E9/B2) serves as an invaluable tool for researchers studying the mechanisms of Influenza B virus pathogenesis and the host immune response, providing insights that could lead to improved strategies for prevention and treatment of influenza infections.

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Influenza B NP Antibody (3E9/B2) References:

1. Immune recognition of HLA molecules downmodulates CD8 expression on cytotoxic T lymphocytes.  |  Robbins, PA. and McMichael, AJ. 1991. J Exp Med. 173: 221-30. PMID: 1898661
2. Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein.  |  Ng, AK., et al. 2012. J Virol. 86: 6758-67. PMID: 22496219
3. Inhibition of influenza A virus replication by influenza B virus nucleoprotein: an insight into interference between influenza A and B viruses.  |  Wanitchang, A., et al. 2012. Virology. 432: 194-203. PMID: 22770925
4. Nuclear import of influenza B virus nucleoprotein: involvement of an N-terminal nuclear localization signal and a cleavage-protection motif.  |  Wanitchang, A., et al. 2013. Virology. 443: 59-68. PMID: 23689061
5. Comparison between two peptide epitopes presented to cytotoxic T lymphocytes by HLA-A2. Evidence for discrete locations within HLA-A2.  |  Robbins, PA., et al. 1989. J Immunol. 143: 4098-103. PMID: 2480387
6. The N terminus of the influenza B virus nucleoprotein is essential for virus viability, nuclear localization, and optimal transcription and replication of the viral genome.  |  Sherry, L., et al. 2014. J Virol. 88: 12326-38. PMID: 25122787
7. The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.  |  Liu, M., et al. 2015. PLoS One. 10: e0137802. PMID: 26368391
8. Complete sequence of the major nucleocapsid protein gene of human parainfluenza type 3 virus: comparison with other negative strand viruses.  |  Jambou, RC., et al. 1986. J Gen Virol. 67 (Pt 11): 2543-8. PMID: 2878059
9. Influenza B virus genome: complete nucleotide sequence of the influenza B/lee/40 virus genome RNA segment 5 encoding the nucleoprotein and comparison with the B/Singapore/222/79 nucleoprotein.  |  Briedis, DJ. and Tobin, M. 1984. Virology. 133: 448-55. PMID: 6324462
10. The N-terminal extension of the influenza B virus nucleoprotein is not required for nuclear accumulation or the expression and replication of a model RNA.  |  Stevens, MP. and Barclay, WS. 1998. J Virol. 72: 5307-12. PMID: 9573310

The preferred Influenza B NP antibody is Influenza B NP Antibody (B017): sc-57885.