Influenza B NP Antibody (1D8/B1): sc-80483
- Influenza B NP Antibody (1D8/B1) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against unpurified Influenza B/Lee/40 virus and purified Influenza B virus
- recommended for detection of nucleoprotein (NP) of Influenza B virus origin by IF; non cross-reactive with Influenza A Virus
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Influenza B NP Antibody (1D8/B1). This work is in progress.
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Influenza B NP Antibody (1D8/B1) is a mouse monoclonal IgG2a antibody that detects Influenza B NP by immunofluorescence (IF). Influenza B NP, or nucleoprotein, plays a crucial role in the viral life cycle as it encapsidates viral RNA, forming ribonucleoprotein complexes essential for transcription and replication of the viral genome. Influenza B NP is primarily located in the nucleus of infected cells, where anti-Influenza B NP antibody (1D8/B1) facilitates the transport of viral RNA to the cytoplasm for protein synthesis and assembly of new virions. Influenza B NP′s ability to interact with various host cell factors is vital for the virus′s ability to hijack cellular machinery, making Influenza B NP a key target for therapeutic interventions and vaccine development. Anti-Influenza B NP antibody (1D8/B1) serves as an invaluable tool for researchers studying the dynamics of Influenza B virus infection and cellular responses, providing insights that are critical for understanding and combating influenza outbreaks.
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Influenza B NP Antibody (1D8/B1) References:
- Expression of influenza A and B virus nucleoprotein antigens in baculovirus. | Rota, PA., et al. 1990. J Gen Virol. 71 (Pt 7): 1545-54. PMID: 2197370
- Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein. | Ng, AK., et al. 2012. J Virol. 86: 6758-67. PMID: 22496219
- Inhibition of influenza A virus replication by influenza B virus nucleoprotein: an insight into interference between influenza A and B viruses. | Wanitchang, A., et al. 2012. Virology. 432: 194-203. PMID: 22770925
- A universal influenza A and B duplex real-time RT-PCR assay. | Lee, HK., et al. 2012. J Med Virol. 84: 1646-51. PMID: 22930514
- Binding of RNA by the Nucleoproteins of Influenza Viruses A and B. | Labaronne, A., et al. 2016. Viruses. 8: PMID: 27649229
- Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. | Tang, YS., et al. 2021. Nucleic Acids Res. 49: 4144-4154. PMID: 33784403
- Evaluation of Three Multiplex Real-time Reverse Transcription PCR Assays for Simultaneous Detection of SARS-CoV-2, Influenza A/B, and Respiratory Syncytial Virus in Nasopharyngeal Swabs. | Yun, J., et al. 2021. J Korean Med Sci. 36: e328. PMID: 34904407
- Characterization and evaluation of monoclonal antibodies developed for typing influenza A and influenza B viruses. | Walls, HH., et al. 1986. J Clin Microbiol. 23: 240-5. PMID: 3517049
- Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses. | Li, P., et al. 2023. J Med Virol. 95: e28968. PMID: 37489704
- The N-terminal extension of the influenza B virus nucleoprotein is not required for nuclear accumulation or the expression and replication of a model RNA. | Stevens, MP. and Barclay, WS. 1998. J Virol. 72: 5307-12. PMID: 9573310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Influenza B NP Antibody (1D8/B1) | sc-80483 | 100 µg/ml | $339.00 |