Influenza B NP Antibody (1B6/B3): sc-80482

Influenza B NP Antibody (1B6/B3) is a mouse monoclonal IgG2a antibody that detects the Influenza B NP protein of Influenza B virus origin by western blotting (WB) and immunofluorescence (IF). Anti-Influenza B NP antibody (1B6/B3) is available as a non-conjugated format. Influenza B nucleoprotein (NP) plays a crucial role in the viral life cycle, as NP is essential for viral RNA encapsidation and viral ribonucleoprotein complex formation. Influenza B NP (1B6/B3) monoclonal antibody protects viral RNA from degradation and facilitates transport to the nucleus, where transcription and replication occur. Influenza B NP′s ability to interact with other viral proteins, such as hemagglutinin and neuraminidase, is vital for assembly and release of new virions, making NP a key target for therapeutic interventions and vaccine development. Understanding Influenza B NP function is important for developing strategies to combat influenza outbreaks, as NP helps researchers identify potential vulnerabilities in the virus that can be targeted by antiviral drugs or vaccines. Influenza B viruses, which are part of the Orthomyxoviridae family, are known for their capacity to undergo antigenic changes, allowing them to evade host immune response, and while they typically cause less severe illness compared to Influenza A, they still pose a significant public health concern.

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Influenza B NP Antibody (1B6/B3) References:

1. Coinfection with influenza B virus does not affect association of Neisseria meningitidis with human nasopharyngeal mucosa in organ culture.  |  Read, RC., et al. 1999. Infect Immun. 67: 3082-6. PMID: 10338524
2. Influenza B virus in seals.  |  Osterhaus, AD., et al. 2000. Science. 288: 1051-3. PMID: 10807575
3. Influenza B and C virus NEP (NS2) proteins possess nuclear export activities.  |  Paragas, J., et al. 2001. J Virol. 75: 7375-83. PMID: 11462009
4. Influenza A and B virus infections in children.  |  Peltola, V., et al. 2003. Clin Infect Dis. 36: 299-305. PMID: 12539071
5. Epidemics of two Victoria and Yamagata influenza B lineages in Yamagata, Japan.  |  Mizuta, K., et al. 2004. Epidemiol Infect. 132: 721-6. PMID: 15310174
6. Detection and characterization of new influenza B virus variants in 2002.  |  Chi, XS., et al. 2005. J Clin Microbiol. 43: 2345-9. PMID: 15872264
7. Second near-infrared fluorescent dye for lateral flow immunoassays rapid detection of influenza A/B virus.  |  Zhang, R., et al. 2022. Anal Biochem. 655: 114847. PMID: 35964731
8. Performance evaluation of the Panbio COVID-19/Flu A&B Panel for detection of SARS-CoV-2, influenza A, and influenza B antigens using mid-turbinate nasal swabs.  |  Yu, S-H., et al. 2024. J Clin Microbiol. 62: e0020724. PMID: 38888305
9. Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains.  |  Krystal, M., et al. 1983. Proc Natl Acad Sci U S A. 80: 4527-31. PMID: 6192436
10. Complete nucleotide sequence of the nucleoprotein gene of influenza B virus.  |  Londo, DR., et al. 1983. J Virol. 47: 642-8. PMID: 6688639
11. Serological diagnosis of influenza B virus infection: comparison of an enzyme-linked immunosorbent assay and the hemagglutination inhibition test.  |  Turner, R., et al. 1982. J Clin Microbiol. 15: 824-9. PMID: 7047553
12. The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template.  |  Jambrina, E., et al. 1997. Virology. 235: 209-17. PMID: 9281500

The preferred Influenza B NP antibody is Influenza B NP Antibody (B017): sc-57885.