Influenza B NA Antibody (MAb B14): sc-66055

Influenza B NA Antibody (MAb B14) is a mouse monoclonal IgM antibody that detects Influenza B NA protein by western blotting (WB). Influenza B NA, or neuraminidase, plays a crucial role in the life cycle of the influenza virus by facilitating the release of newly formed viral particles from infected cells. This enzymatic activity is essential for the spread of the virus within the host, as it cleaves sialic acid residues on the surface of host cells, allowing the virus to escape and infect neighboring cells. The importance of neuraminidase in viral pathogenesis makes it a key target for antiviral drugs, such as oseltamivir (Tamiflu), which inhibit its function and thereby limit the spread of the virus. Anti-Influenza B NA antibody (MAb B14) enables researchers to effectively study the expression and function of neuraminidase, contributing to a better understanding of influenza virus biology and the development of therapeutic strategies.

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Influenza B NA Antibody (MAb B14) References:

1. Neuraminidase inhibitors for influenza B virus infection: efficacy and resistance.  |  Burnham, AJ., et al. 2013. Antiviral Res. 100: 520-34. PMID: 24013000
2. Functional balance between neuraminidase and haemagglutinin in influenza viruses.  |  Gaymard, A., et al. 2016. Clin Microbiol Infect. 22: 975-983. PMID: 27424943
3. Broadly protective human antibodies that target the active site of influenza virus neuraminidase.  |  Stadlbauer, D., et al. 2019. Science. 366: 499-504. PMID: 31649200
4. Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl.  |  Sacramento, CQ., et al. 2020. Curr Top Med Chem. 20: 132-139. PMID: 31880262
5. Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors.  |  Brown, SK., et al. 2022. Antiviral Res. 200: 105280. PMID: 35304163
6. Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle.  |  Kim, KH., et al. 2022. PLoS Pathog. 18: e1010755. PMID: 36006890
7. A pan-influenza antibody inhibiting neuraminidase via receptor mimicry.  |  Momont, C., et al. 2023. Nature. 618: 590-597. PMID: 37258672
8. Influenza B virus neuraminidase: a potential target for next-generation vaccines?  |  Do, THT., et al. 2024. Expert Rev Vaccines. 23: 39-48. PMID: 38037386
9. Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface.  |  Wolters, RM., et al. 2024. Immunity. 57: 1413-1427.e9. PMID: 38823390
10. Influenza neuraminidase mutations and resistance to neuraminidase inhibitors.  |  Xu, J., et al. 2024. Emerg Microbes Infect. 13: 2429627. PMID: 39530458

The preferred Influenza B NA antibody is Influenza B NA Antibody (MAb B19): sc-66056.