Influenza A m1 Antibody (GA2B): sc-57881
- Influenza A m1 Antibody (GA2B) is a mouse monoclonal IgG1, cited in 7 publications, provided at 100 µg/ml
- raised against Influenza A/Puerto Rico/8/34 (H1N1) and A/Bangkok/1/79 (H3N2) viruses
- recommended for detection of Influenza type A matrix 1 protein, m1 of Influenza A Virus origin by IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Influenza A m1 Antibody (GA2B). This work is in progress.
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Influenza A m1 Antibody (GA2B) is a mouse monoclonal IgG1 antibody that detects Influenza A m1 protein by immunofluorescence (IF). Influenza A m1 monoclonal antibody (GA2B) recognizes a pivotal protein in the influenza virus life cycle, playing a crucial role in assembly and budding processes essential for viral propagation. This matrix protein is located in the viral envelope, where anti-Influenza A m1 antibody (GA2B) can detect its interactions with other viral proteins, such as hemagglutinin (HA) and neuraminidase (NA), which facilitate the formation of new viral particles. The interaction between m1 and HA is particularly important, as HA′s cytoplasmic tail and transmembrane domain associate with m1, ensuring proper viral assembly. Understanding the function and location of m1 is vital, as this protein contributes to viral structural integrity and influences replication efficiency and overall pathogenicity of Influenza A viruses. Using Influenza A m1 (GA2B) monoclonal antibody in research can provide valuable insights into influenza virus assembly mechanisms and potential therapeutic targets.
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Influenza A m1 Antibody (GA2B) References:
- The crystal structure of the influenza matrix protein M1 at neutral pH: M1-M1 protein interfaces can rotate in the oligomeric structures of M1. | Harris, A., et al. 2001. Virology. 289: 34-44. PMID: 11601915
- Interaction of influenza A virus matrix protein with RACK1 is required for virus release. | Demirov, D., et al. 2012. Cell Microbiol. 14: 774-89. PMID: 22289149
- A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication. | Cao, S., et al. 2012. J Virol. 86: 4883-91. PMID: 22345442
- The functional CD8 T cell memory recall repertoire responding to the influenza A M1(58-66) epitope is polyclonal and shows a complex clonotype distribution. | Zhou, V., et al. 2013. Hum Immunol. 74: 809-17. PMID: 23295548
- Secondary structure of a conserved domain in an intron of influenza A M1 mRNA. | Jiang, T., et al. 2014. Biochemistry. 53: 5236-48. PMID: 25026548
- Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation. | Beigel, JH., et al. 2018. Br J Clin Pharmacol. 84: 25-34. PMID: 28929521
- Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages. | Masemann, D., et al. 2018. Oncoimmunology. 7: e1423171. PMID: 29721377
- Amphipathic CRAC-Containing Peptides Derived from the Influenza Virus A M1 Protein Modulate Cholesterol-Dependent Activity of Cultured IC-21 Macrophages. | Dunina-Barkovskaya, AY., et al. 2018. Biochemistry (Mosc). 83: 982-991. PMID: 30208834
- Protein Folding Interdiction Strategy for Therapeutic Drug Development in Viral Diseases: Ebola VP40 and Influenza A M1. | Bergasa-Caceres, F. and Rabitz, HA. 2022. Int J Mol Sci. 23: PMID: 35409264
- Role of cross-reactivity in cellular immune targeting of influenza A M158-66 variant peptide epitopes. | Petrova, GV., et al. 2022. Front Immunol. 13: 956103. PMID: 36211433
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Influenza A m1 Antibody (GA2B) | sc-57881 | 100 µg/ml | $322.00 |