Influenza A m1 Antibody (FluAc): sc-69824

Influenza A m1 Antibody (FluAc) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Influenza A m1 protein of Influenza A Virus origin by western blotting (WB) and immunofluorescence (IF). Anti-Influenza A m1 antibody (FluAc) is available as the non-conjugated format. Influenza A m1 protein plays a crucial role in the viral life cycle, particularly in assembly and budding processes of the virus. Influenza A m1 protein is located in the viral envelope and maintains structural integrity during these stages. Influenza A m1 protein interacts with other viral proteins, such as hemagglutinin (HA) and neuraminidase (NA), which are vital for virus′s ability to infect host cells. HA associates with Influenza A m1 protein through cytoplasmic tail and transmembrane domain, facilitating proper assembly of the viral envelope. Understanding Influenza A m1 protein function and location is important for developing antiviral strategies, as targeting this protein could disrupt viral replication and spread. Influenza viruses are categorized into three types—A, B, and C—with types A and B being responsible for seasonal epidemics of respiratory illness. Detection and study of Influenza A m1 protein using anti-Influenza A m1 antibody (FluAc) is essential for research aimed at combating influenza outbreaks and improving public health responses.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Influenza A m1 Antibody (FluAc) References:

1. Experimentally based orientational refinement of membrane protein models: A structure for the Influenza A M2 H+ channel.  |  Kukol, A., et al. 1999. J Mol Biol. 286: 951-62. PMID: 10024461
2. Mechanism for proton conduction of the M(2) ion channel of influenza A virus.  |  Mould, JA., et al. 2000. J Biol Chem. 275: 8592-9. PMID: 10722698
3. Influenza virus assembly: effect of influenza virus glycoproteins on the membrane association of M1 protein.  |  Ali, A., et al. 2000. J Virol. 74: 8709-19. PMID: 10954572
4. Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR.  |  Lawson, TM., et al. 2001. Int Immunol. 13: 1383-90. PMID: 11675370
5. Update on influenza and other viral pneumonias.  |  Fleming, DM. and Zambon, M. 2001. Curr Opin Infect Dis. 14: 199-204. PMID: 11979133
6. Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus life cycle.  |  Watanabe, K., et al. 2006. FEBS Lett. 580: 5785-90. PMID: 17022977
7. Secondary structure of a conserved domain in an intron of influenza A M1 mRNA.  |  Jiang, T., et al. 2014. Biochemistry. 53: 5236-48. PMID: 25026548
8. Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires.  |  Aslan, N., et al. 2017. mBio. 8: PMID: 29208744
9. Amphipathic CRAC-Containing Peptides Derived from the Influenza Virus A M1 Protein Modulate Cholesterol-Dependent Activity of Cultured IC-21 Macrophages.  |  Dunina-Barkovskaya, AY., et al. 2018. Biochemistry (Mosc). 83: 982-991. PMID: 30208834
10. Protein Folding Interdiction Strategy for Therapeutic Drug Development in Viral Diseases: Ebola VP40 and Influenza A M1.  |  Bergasa-Caceres, F. and Rabitz, HA. 2022. Int J Mol Sci. 23: PMID: 35409264
11. Role of cross-reactivity in cellular immune targeting of influenza A M158-66 variant peptide epitopes.  |  Petrova, GV., et al. 2022. Front Immunol. 13: 956103. PMID: 36211433
12. A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.  |  Pinto, LH., et al. 1997. Proc Natl Acad Sci U S A. 94: 11301-6. PMID: 9326604

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Influenza A m1 Antibody (FluAc) has 11 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Influenza A m1 Antibody (FluAc) Specifications

Alternate Product Name: Influenza A Matrix-1 (M1) protein

Product Clone Name: FluAc

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Influenza A m1

Epitope Species: influenza A virus

Product Reactivity/Detection: Influenza A m1

Species Reactivity/Detection: Influenza A Virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for Influenza A m1 Antibody (FluAc): N/A