ILPIP Antibody (F-10): sc-390494

ILPIP Antibody (F-10) is a mouse monoclonal IgM kappa antibody that detects ILPIP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-ILPIP antibody (F-10) is available as the non-conjugated form. ILPIP protein, also known as ILP-interacting protein or amyotrophic lateral sclerosis 2 juvenile chromosome region gene 2 (ALS2CR2), plays a crucial role in cellular signaling by interacting with X-linked IAP (XIAP), a member of the inhibitor of apoptosis protein (IAP) family. This interaction is significant because IAPs, including XIAP, are known to inhibit caspases, which are essential for the execution phase of apoptosis. By enhancing XIAP-mediated activation of the TGFβ-activated kinase 1/c-Jun NH2-terminal kinase 1 (TAK1/JNK1) signaling pathway, ILPIP contributes to cellular protection against apoptosis induced by interleukin-1β and FAS. Notably, the protective effect of ILPIP against apoptosis is caspase-independent, highlighting ILPIP′s potential as a therapeutic target in cancer, where IAPs are implicated in the development and progression of both solid tumors and hematologic malignancies. When expressed alone, ILPIP moderately activates the TAK1/JNK1 signaling pathway, underscoring ILPIP′s role in modulating cell survival and apoptosis.

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ILPIP Antibody (F-10) References:

1. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.  |  Hadano, S., et al. 2001. Genomics. 71: 200-13. PMID: 11161814
2. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.  |  Sanna, MG., et al. 2002. J Biol Chem. 277: 30454-62. PMID: 12048196
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.  |  Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
5. Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy.  |  Schimmer, AD. and Dalili, S. 2005. Hematology Am Soc Hematol Educ Program. 215-9. PMID: 16304383

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ILPIP Antibody (F-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ILPIP Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ILPIP Antibody (F-10) Specifications

Alternate Product Name: ILPIP

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 66-85

Epitope Target: ILPIP

Epitope Species: human

Product Reactivity/Detection: ILPIP-α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ILPIP Antibody (F-10): P: Blocking Peptide