ILKAP Antibody (41): sc-136341

ILKAP Antibody (41) is a mouse monoclonal IgG1 kappa light chain antibody that detects ILKAP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-ILKAP antibody (41) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). ILKAP, also known as integrin-linked kinase-associated serine/threonine phosphatase 2C or PP2C-delta, is a 392 amino acid cytoplasmic protein phosphatase that plays a crucial role in regulating growth factor signaling and cell adhesion by selectively interacting with integrin-linked kinase (ILK). This interaction is vital for maintaining cellular functions and ensuring proper responses to extracellular signals, which can influence processes such as cell migration, proliferation, and survival. ILKAP is predominantly expressed in striated muscle, with lower expression levels in smooth muscle, highlighting its importance in muscle physiology. As a member of the PP2C family, ILKAP contains a PP2C-like domain and binds two magnesium or manganese ions per subunit as cofactors, which are essential for phosphatase activity. The gene encoding ILKAP is located on human chromosome 2, a region that encompasses 237 million bases and encodes over 1,400 genes, representing approximately 8% of the human genome.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ILKAP Antibody (41) References:

1. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.  |  Leung-Hagesteijn, C., et al. 2001. EMBO J. 20: 2160-70. PMID: 11331582
2. ILKAP regulates ILK signaling and inhibits anchorage-independent growth.  |  Kumar, AS., et al. 2004. Oncogene. 23: 3454-61. PMID: 14990992
3. PP2C family members play key roles in regulation of cell survival and apoptosis.  |  Tamura, S., et al. 2006. Cancer Sci. 97: 563-7. PMID: 16827794
4. Expression of stress inducible protein 1 (Stip1) in the mouse testis.  |  Mizrak, SC., et al. 2006. Mol Reprod Dev. 73: 1361-6. PMID: 16894550
5. Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling.  |  Lammers, T. and Lavi, S. 2007. Crit Rev Biochem Mol Biol. 42: 437-61. PMID: 18066953
6. Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1.  |  Nakrieko, KA., et al. 2008. Cell Cycle. 7: 2157-66. PMID: 18635968
7. Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes.  |  Pridgeon, JW., et al. 2009. FEBS J. 276: 118-31. PMID: 19019082
8. Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling.  |  Jin, H., et al. 2021. J Cell Mol Med. 25: 11075-11084. PMID: 34734476
9. Intracellular targeting of STIP1 inhibits human cancer cell line growth.  |  Lin, CY., et al. 2021. Transl Cancer Res. 10: 1313-1323. PMID: 35116457
10. Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression.  |  Wang, W., et al. 2024. Cancer Lett. 591: 216849. PMID: 38621458
11. Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer.  |  Xu, P., et al. 2024. Nat Commun. 15: 6626. PMID: 39103353
12. Cloning and characterization of a novel mammalian PP2C isozyme.  |  Tong, Y., et al. 1998. J Biol Chem. 273: 35282-90. PMID: 9857069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ILKAP Antibody (41) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ILKAP Antibody (41) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ILKAP Antibody (41) Specifications

Alternate Product Name: ILKAP

Product Clone Name: 41

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 38-144

Epitope Target: ILKAP

Epitope Species: rat

Product Reactivity/Detection: ILKAP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ILKAP Antibody (41): AC: Agarose, HRP: Horseradish Peroxidase