IL-7 Antibody (NYRhIL7): sc-73320

IL-7 Antibody (NYRhIL7) is a mouse monoclonal IgG1 antibody that detects interleukin-7 (IL-7) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IL-7 is a crucial cytokine that plays a significant role in the development and homeostasis of T and B lymphocytes, making IL-7 essential for a robust immune response. IL-7 is primarily secreted by stromal cells in the bone marrow and thymus, where IL-7 binds to the IL-7 receptor on lymphocyte precursors, promoting their survival and proliferation. This interaction is vital for the maturation of T cells and the maintenance of memory T cells, which are critical for long-term immunity. Additionally, IL-7′s ability to stimulate the activation of Janus tyrosine kinase family members, such as JAK1 and JAK3, underscores IL-7′s importance in signaling pathways that regulate immune cell function. Anti-IL-7 antibody (NYRhIL7) is an invaluable tool for researchers studying immune responses, lymphocyte development, and potential therapeutic targets in immunological disorders.

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IL-7 Antibody (NYRhIL7) References:

1. IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.  |  Cieri, N., et al. 2013. Blood. 121: 573-84. PMID: 23160470
2. Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells.  |  Coppola, C., et al. 2020. Int J Mol Sci. 21: PMID: 33105566
3. IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin.  |  Pang, N., et al. 2021. J Hematol Oncol. 14: 118. PMID: 34325726
4. IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant.  |  Bekele, Y., et al. 2021. Front Immunol. 12: 737406. PMID: 34603318
5. The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy.  |  Wang, C., et al. 2022. Int J Mol Sci. 23: PMID: 36142322
6. IL-7 receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK inhibition.  |  Courtois, L., et al. 2023. Blood. 142: 158-171. PMID: 37023368
7. IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.  |  Kaiser, FMP., et al. 2023. Blood. 142: 1113-1130. PMID: 37369082
8. IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy.  |  Lee, KJ., et al. 2024. Cell Rep Med. 5: 101567. PMID: 38744277
9. A human autoimmune organoid model reveals IL-7 function in coeliac disease.  |  Santos, AJM., et al. 2024. Nature. 632: 401-410. PMID: 39048815
10. IL-7 promotes mRNA vaccine-induced long-term immunity.  |  Wang, L., et al. 2024. J Nanobiotechnology. 22: 716. PMID: 39550592

The preferred IL-7 antibody is IL-7 Antibody (D-9): sc-365306.