IL-4Rα Antibody (E-1): sc-165974
- IL-4Rα Antibody (E-1) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 511-810 of IL-4Ra of mouse origin
- Anti-IL-4R alpha Antibody (E-1) is recommended for detection of IL-4Rα of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IL-4R alpha Antibody (E-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IL-4Rα Antibody (E-1) for WB and IHC(P) applications. These reagents are now offered in bundles with IL-4Rα Antibody (E-1) (see ordering information below).
QUICK LINKS
SEE ALSO...
IL-4Rα Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-4Rα in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-IL-4Rα antibody (E-1) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for different experimental needs. IL-4 receptor alpha (IL-4Rα) plays a crucial role in the immune response by mediating the effects of interleukin-4, a key cytokine involved in the differentiation of T helper cells and the regulation of immune responses. IL-4Rα is primarily located on the surface of immune cells, including T cells, B cells, and macrophages, where IL-4Rα facilitates the binding of IL-4 and initiates signaling pathways that promote cell proliferation and differentiation. This surface expression ensures immune cells can respond effectively to cytokine signals, thereby influencing the development of allergic responses and the regulation of inflammation. Understanding IL-4Rα dynamics and interactions is essential for developing targeted therapies for various immune-related disorders, including asthma and other allergic conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-4Rα Antibody (E-1) References:
- Skeletal muscle IL-4, IL-4Ralpha, IL-13 and IL-13Ralpha1 expression and response to strength training. | Prokopchuk, O., et al. 2007. Exerc Immunol Rev. 13: 67-75. PMID: 18198661
- The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology. | Heitmann, L., et al. 2014. J Pathol. 234: 338-50. PMID: 24979482
- Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling. | Ahmed, N., et al. 2015. Cell Physiol Biochem. 36: 831-42. PMID: 26044177
- Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load. | Hadebe, S., et al. 2021. J Allergy Clin Immunol. 148: 99-109.e5. PMID: 33383090
- Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. | Damen, MSMA., et al. 2021. Int J Obes (Lond). 45: 2377-2387. PMID: 34302121
- Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Rα. | Liu, Q., et al. 2022. Inflamm Res. 71: 1271-1282. PMID: 35922673
- Alpha-linolenic acid improves nasal mucosa epithelial barrier function in allergic rhinitis by arresting CD4+ T cell differentiation via IL-4Rα-JAK2-STAT3 pathway. | Ding, Y., et al. 2023. Phytomedicine. 116: 154825. PMID: 37178572
- IL-4Rα Inhibition for Severe 'Eosinophilic Gastroenteritis, Allergy, and Anaphylaxis' Syndrome due to a Gain-of-Function Variant in STAT6. | Faguer, S., et al. 2023. J Clin Immunol. 44: 29. PMID: 38133747
- Proteomic, miRNA and bacterial biomarker patterns in atopic dermatitis patients and their course upon anti-IL-4Rα therapy. | Pažur, K., et al. 2024. J Eur Acad Dermatol Venereol. 38: 1749-1759. PMID: 38379385
- Non-invasive strategy: Developing a topical IL-4Rα-specific nanobody for the treatment of allergic airway diseases. | Ahn, T., et al. 2024. Mater Today Bio. 27: 101148. PMID: 39108557
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-4Rα Antibody (E-1) | sc-165974 | 200 µg/ml | $316.00 | |||
IL-4Rα Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-527132 | 200 µg Ab; 10 µg BP | $354.00 | |||
IL-4Rα Antibody (E-1): m-IgG1 BP-HRP Bundle | sc-532505 | 200 µg Ab; 20 µg BP | $354.00 | |||
IL-4Rα Antibody (E-1) AC | sc-165974 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IL-4Rα Antibody (E-1) HRP | sc-165974 HRP | 200 µg/ml | $316.00 | |||
IL-4Rα Antibody (E-1) FITC | sc-165974 FITC | 200 µg/ml | $330.00 | |||
IL-4Rα Antibody (E-1) PE | sc-165974 PE | 200 µg/ml | $343.00 | |||
IL-4Rα Antibody (E-1) Alexa Fluor® 488 | sc-165974 AF488 | 200 µg/ml | $357.00 | |||
IL-4Rα Antibody (E-1) Alexa Fluor® 546 | sc-165974 AF546 | 200 µg/ml | $357.00 | |||
IL-4Rα Antibody (E-1) Alexa Fluor® 594 | sc-165974 AF594 | 200 µg/ml | $357.00 | |||
IL-4Rα Antibody (E-1) Alexa Fluor® 647 | sc-165974 AF647 | 200 µg/ml | $357.00 | |||
IL-4Rα Antibody (E-1) Alexa Fluor® 680 | sc-165974 AF680 | 200 µg/ml | $357.00 | |||
IL-4Rα Antibody (E-1) Alexa Fluor® 790 | sc-165974 AF790 | 200 µg/ml | $357.00 |