IL-3/IL-5/GM-CSFRβ Antibody (C-4): sc-376582
- IL-3/IL-5/GM-CSFRβ Antibody (C-4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 869-897 at the C-terminus of IL-3/IL-5/GM-CSFRβ of human origin
- recommended for detection of IL-3/IL-5/GM-CSFRβ of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-3/IL-5/GM-CSFRβ Antibody (C-4). This work is in progress.
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IL-3/IL-5/GM-CSFRβ Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects IL-3/IL-5/GM-CSFRβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-3/IL-5/GM-CSFRβ plays a crucial role in hematopoiesis by serving as a common β subunit for the receptors of interleukin-3, interleukin-5, and granulocyte-macrophage colony-stimulating factor, which are essential for the proliferation and differentiation of various blood cells. IL-3/IL-5/GM-CSFRβ location in the cell membrane facilitates the binding of specific ligands to the unique α subunits, thereby initiating signaling cascades that lead to cellular responses. While the human β subunit does not possess intrinsic tyrosine kinase activity, IL-3/IL-5/GM-CSFRβ remains vital for the activation of downstream signaling pathways that rely on tyrosine phosphorylation, underscoring its significance in immune response and hematopoietic regulation. Anti-IL-3/IL-5/GM-CSFRβ antibody (C-4) serves as an invaluable tool for researchers studying these critical pathways in human biology.
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IL-3/IL-5/GM-CSFRβ Antibody (C-4) References:
- Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. | Geijsen, N., et al. 2001. Cytokine Growth Factor Rev. 12: 19-25. PMID: 11312115
- The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. | Asquith, KL., et al. 2008. J Immunol. 180: 1199-206. PMID: 18178860
- Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. | Fortin, M., et al. 2010. Cytokine. 52: 194-202. PMID: 20696593
- CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors. | Panousis, C., et al. 2016. MAbs. 8: 436-53. PMID: 26651396
- The Prospects of an Active Vaccine Against Asthma Targeting IL-5. | Bachmann, MF., et al. 2018. Front Microbiol. 9: 2522. PMID: 30405579
- Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF. | Nelson, RK., et al. 2019. J Immunol. 203: 329-337. PMID: 31175163
- Divergent effects of Wnt5b on IL-3- and GM-CSF-induced myeloid differentiation. | de Rezende, MM., et al. 2020. Cell Signal. 67: 109507. PMID: 31857239
- IL-3 Expands Pre-Basophil and Mast Cell Progenitors by Upregulating the IL-3 Receptor Expression. | Li, Y., et al. 2022. Cell Immunol. 374: 104498. PMID: 35334276
- IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma. | Luo, J., et al. 2024. Mucosal Immunol. 17: 524-536. PMID: 38493955
- Serum concentrations of IL-5, GM-CSF, and IL-3 and the production by lymphocytes in various eosinophilia. | Koike, T., et al. 1995. Am J Hematol. 50: 98-102. PMID: 7573007
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-3/IL-5/GM-CSFRβ Antibody (C-4) | sc-376582 | 200 µg/ml | $322.00 | |||
IL-3/IL-5/GM-CSFRβ (C-4) Neutralizing Peptide | sc-376582 P | 100 µg/0.5 ml | $69.00 |