IL-2Rβ Antibody (D-12): sc-376003

IL-2Rβ Antibody (D-12) is a mouse monoclonal IgG1 antibody that detects IL-2Rβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2Rβ, a critical component of the interleukin-2 receptor complex, plays a vital role in the immune response by mediating signaling pathways that lead to T cell proliferation and differentiation. IL-2Rβ is primarily located on the surface of T cells, where IL-2Rβ forms a high-affinity receptor for interleukin-2 when associated with the α and γ chains. IL-2Rβ expression on T cells is essential for their activation and survival, making IL-2Rβ a key player in the regulation of immune responses. Notably, IL-2Rβ interaction with IL-2 not only enhances T cell growth but also influences the development of regulatory T cells, which are crucial for maintaining immune tolerance and preventing autoimmune diseases. Anti-IL-2Rβ antibody (D-12) is therefore an invaluable tool for researchers studying T cell biology and the mechanisms underlying immune regulation.

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IL-2Rβ Antibody (D-12) References:

1. Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor beta chain.  |  Goebel, J., et al. 2005. J Investig Med. 53: 322-8. PMID: 16207471
2. Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain.  |  Yamashita, Y., et al. 2008. J Cell Sci. 121: 1727-38. PMID: 18445679
3. Interleukin-3-induced downregulation of the expression of interleukin-2 receptor beta chain in human T cells.  |  Onishi, R., et al. 1991. Blood. 78: 2908-17. PMID: 1954379
4. Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain and the common γ-chain.  |  Izumi, T., et al. 2013. Cytotherapy. 15: 481-91. PMID: 23391461
5. Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal.  |  Okamoto, Y., et al. 1990. Proc Natl Acad Sci U S A. 87: 6584-8. PMID: 2395860
6. IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells.  |  Smith, GA., et al. 2017. Sci Signal. 10: PMID: 29259099
7. Coexpression of Fc gamma receptor IIIA and interleukin-2 receptor beta chain by a subset of human CD3+/CD8+/CD11b+ lymphocytes.  |  Zupo, S., et al. 1993. J Clin Immunol. 13: 228-36. PMID: 7686565
8. Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.  |  Lin, JX., et al. 1993. Mol Cell Biol. 13: 6201-10. PMID: 8413220
9. Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain.  |  Stevens, AC., et al. 1997. Am J Physiol. 272: G1201-8. PMID: 9176231
10. In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.  |  Youn, J., et al. 1998. J Exp Med. 188: 1803-16. PMID: 9815258

The preferred IL-2Rβ antibody is IL-2Rβ Antibody (C-2): sc-166427.