IL-2Rα Antibody (IL2R.1): sc-57297

IL-2Rα Antibody (IL2R.1) is a mouse monoclonal IgG1 antibody that detects IL-2Rα in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). IL-2Rα, also known as CD25, plays a crucial role in the immune system by serving as a high-affinity receptor for interleukin-2 (IL-2), a key cytokine involved in T cell proliferation and differentiation. Anti-IL-2Rα antibody (IL2R.1) recognizes a protein primarily located on the surface of activated T cells, where IL-2Rα facilitates IL-2 binding, leading to the formation of the high-affinity IL-2 receptor complex alongside the β and γ chains. This complex is vital for initiating signaling pathways that promote T cell growth and function, underscoring IL-2Rα′s importance in both adaptive and innate immunity. Furthermore, aberrations in IL-2Rα expression can be associated with various immune disorders and malignancies, highlighting IL-2Rα′s potential as a therapeutic target and a biomarker for disease progression. IL-2Rα monoclonal antibody (IL2R.1) serves as an invaluable tool for researchers investigating the dynamics of T cell responses and the broader implications of cytokine signaling in human health and disease.

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IL-2Rα Antibody (IL2R.1) References:

1. Distinctions in lymphocyte responses to IL-2 and IL-15 reflect differential ligand binding interactions with the IL-2Rbeta chain and suggest differential roles for the IL-2Ralpha and IL-15Ralpha subunits.  |  de Jong, JL., et al. 1998. Cytokine. 10: 920-30. PMID: 10049515
2. Effect of anti-IL-2Ralpha antibody on IL-2-induced Jak/STAT signaling.  |  Tkaczuk, J., et al. 2002. Am J Transplant. 2: 31-40. PMID: 12095053
3. CD4(-)c-kit(-)CD3epsilon(-)IL-2Ralpha(+) Peyer's patch cells are a novel cell subset which secrete IL-5 in response to IL-2: implications for their role in IgA production.  |  Kuraoka, M., et al. 2004. Eur J Immunol. 34: 1920-9. PMID: 15214040
4. Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275.  |  Reddy, M., et al. 2007. Cell Immunol. 247: 1-11. PMID: 17761156
5. Differential modulation by IL-17A of Cholangitis versus Colitis in IL-2Rα deleted mice.  |  Yang, W., et al. 2014. PLoS One. 9: e105351. PMID: 25133396
6. Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells.  |  Toomer, KH., et al. 2019. Nat Commun. 10: 1037. PMID: 30833563
7. IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2Rα therapies.  |  Volkó, J., et al. 2019. Proc Natl Acad Sci U S A. 116: 21120-21130. PMID: 31570576
8. IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells.  |  Wong, VA., et al. 2024. Front Immunol. 15: 1369818. PMID: 38812502
9. IL-2Rα is a potential biomarker for heart failure diagnosis of patients with end-stage renal disease and haemodialysis.  |  Lv, B., et al. 2025. ESC Heart Fail. 12: 118-132. PMID: 39263807
10. Interleukin-2 receptor α (IL-2Rα/CD25) shedding is differentially regulated by N- and O-glycosylation.  |  Franke, A., et al. 2024. Biochim Biophys Acta Mol Cell Res. 1872: 119863. PMID: 39427744

The preferred IL-2Rα antibody is IL-2Rα Antibody (C-9): sc-393326.