IL-2Rα Antibody (G-7): sc-365912

IL-2Rα Antibody (G-7) is a mouse monoclonal IgM antibody that detects IL-2Rα in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2Rα, also known as CD25, plays a crucial role in the immune system by serving as a high-affinity receptor for interleukin-2 (IL-2), a key cytokine involved in T cell proliferation and differentiation. Anti-IL-2Rα antibody (G-7) recognizes a protein essential for T cell activation and survival, particularly during immune responses, making IL-2Rα a vital component in regulating immune function. IL-2Rα is primarily located on the surface of activated T cells, where IL-2Rα forms a multicomponent receptor complex with the β and γ chains, facilitating IL-2 binding and triggering downstream signaling pathways that promote T cell growth and function. The interaction of IL-2 with IL-2Rα is critical for maintaining immune homeostasis and preventing autoimmune diseases, highlighting IL-2Rα′s importance in both health and disease. Anti-IL-2Rα antibody (G-7) serves as an invaluable tool for researchers studying T cell biology, cytokine signaling, and the therapeutic potential of targeting IL-2 pathways in various immunological disorders.

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IL-2Rα Antibody (G-7) References:

1. Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.  |  Matikainen, S., et al. 1999. Blood. 93: 1980-91. PMID: 10068671
2. Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts.  |  Vereb, G., et al. 2000. Proc Natl Acad Sci U S A. 97: 6013-8. PMID: 10823948
3. Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development.  |  Yeh, JH., et al. 2002. Nucleic Acids Res. 30: 1944-51. PMID: 11972331
4. Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites.  |  Imbert, V., et al. 2002. Eur Cytokine Netw. 13: 331-9. PMID: 12231477
5. A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.  |  Sampson, JH., et al. 2012. PLoS One. 7: e31046. PMID: 22383993
6. Elevated soluble IL-2Rα, IL-8, and MIP-1β levels are associated with inferior outcome and are independent of MIPI score in patients with mantle cell lymphoma.  |  Sonbol, MB., et al. 2014. Am J Hematol. 89: E223-7. PMID: 25164110
7. The c.305del3 in IL-2 gene in Homonoidea theoretically affects IL-2/IL-2Rα interaction as well as lymphocyte homeostasis.  |  Hosseinian, H., et al. 2018. Cytokine. 108: 232-238. PMID: 29246655
8. A panel containing PD-1, IL-2Rα, IL-10, and CA15-3 as a biomarker to discriminate breast cancer from benign breast disease.  |  Liu, C., et al. 2018. Cancer Manag Res. 10: 1749-1761. PMID: 29983594
9. Soluble IL-2Rα correlates with imbalances of Th1/Th2 and Tc1/Tc2 cells in patients with acute brucellosis.  |  Sun, HL., et al. 2020. Infect Dis Poverty. 9: 92. PMID: 32660627
10. Corrigendum to 'Improving the expression of anti-IL-2Rα monoclonal antibody in the CHO cells through optimization of the expression vector and translation efficiency' [J. Biotechnol. 324 (2020) 112-120].  |  Hoseinpoor, R., et al. 2021. J Biotechnol. 325: 397. PMID: 33243465

The preferred IL-2Rα antibody is IL-2Rα Antibody (C-9): sc-393326.