IL-2Rα Antibody (C-11): sc-365511

IL-2Rα Antibody (C-11) is a mouse monoclonal IgG2b antibody that detects IL-2Rα in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2Rα, also known as CD25, plays a crucial role in the immune response by serving as a high-affinity receptor for interleukin-2 (IL-2), a key cytokine involved in T cell proliferation and differentiation. Anti-IL-2Rα antibody (C-11) recognizes a protein essential for T cell activation and survival, making IL-2Rα a critical component in immune response regulation. Notably, IL-2Rα is primarily located on the surface of activated T cells, where IL-2Rα forms a multicomponent receptor complex with the β and γ chains, facilitating IL-2 binding and triggering downstream signaling pathways that promote T cell growth and function. The interaction of IL-2 with IL-2Rα is vital for maintaining immune homeostasis and preventing autoimmune diseases, highlighting IL-2Rα′s importance in both normal immune function and potential therapeutic applications. IL-2Rα monoclonal antibody (C-11) serves as an invaluable tool for researchers studying T cell biology and immune regulation mechanisms.

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IL-2Rα Antibody (C-11) References:

1. IL-2Ralpha-Directed monoclonal antibodies provide effective therapy in a murine model of adult T-cell leukemia by a mechanism other than blockade of IL-2/IL-2Ralpha interaction.  |  Phillips, KE., et al. 2000. Cancer Res. 60: 6977-84. PMID: 11156399
2. NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component, and with low molecular weight compounds that inhibit the IL-2/IL-Ralpha interaction.  |  Emerson, SD., et al. 2003. Protein Sci. 12: 811-22. PMID: 12649439
3. Soluble IL-2Rα facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma.  |  Yang, ZZ., et al. 2011. Blood. 118: 2809-20. PMID: 21719603
4. Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice.  |  Russell, SE., et al. 2012. PLoS One. 7: e47748. PMID: 23077668
5. Monitoring of TNFR1, IL-2Rα, HGF, CCL8, IL-8 and IL-12p70 following HSCT and their role as GVHD biomarkers in paediatric patients.  |  Berger, M., et al. 2013. Bone Marrow Transplant. 48: 1230-6. PMID: 23584443
6. Functional NK cell repertoires are maintained through IL-2Rα and Fas ligand.  |  Felices, M., et al. 2014. J Immunol. 192: 3889-97. PMID: 24634493
7. Comprehensive serum cytokine analysis identifies IL-1RA and soluble IL-2Rα as predictors of event-free survival in T-cell lymphoma.  |  Gupta, M., et al. 2016. Ann Oncol. 27: 165-72. PMID: 26487586
8. IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma.  |  Wang, L., et al. 2018. Cancer Commun (Lond). 38: 62. PMID: 30340635
9. T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.  |  Mullins, GN., et al. 2020. Sci Rep. 10: 21994. PMID: 33319815
10. IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8+ T Cells.  |  Buhelt, S., et al. 2021. Front Immunol. 12: 676141. PMID: 34386002

The preferred IL-2Rα antibody is IL-2Rα Antibody (C-9): sc-393326.