IL-21R Antibody (H-11): sc-137120

IL-21R Antibody (H-11) is a mouse monoclonal IgG3 kappa light chain antibody that detects IL-21R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-21R (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-21 receptor, also known as IL-21R, NILR, or novel interleukin receptor, is a type I cytokine receptor that plays a crucial role in immune regulation by forming a complex with the common gamma chain (γc) to mediate IL-21 signaling. IL-21R is predominantly located on the surface of natural killer cells, B cells, and T cells, with particularly high expression levels in the spleen and thymus, which are vital sites for lymphocyte development and function. IL-21 and IL-21R interaction is essential for promoting lymphoid proliferation and facilitating the transition from innate to adaptive immunity. Notably, tumor necrosis factor (TNF) can upregulate IL-21R expression, and TNF and IL-21 combination has been shown to synergistically enhance myeloma cell proliferation through signaling pathways involving the phosphorylation of JAK1, Stat3, and Erk1/2. Human IL-21R gene is located on chromosome 16p11 and encodes a 538 amino acid protein that shares a 62% sequence identity with mouse Il21r, highlighting the evolutionary conservation of this important immune receptor.

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IL-21R Antibody (H-11) References:

1. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.  |  Parrish-Novak, J., et al. 2000. Nature. 408: 57-63. PMID: 11081504
2. Cytokines: IL-21 joins the gamma(c)-dependent network?  |  Vosshenrich, CA. and Di Santo, JP. 2001. Curr Biol. 11: R175-7. PMID: 11267886
3. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.  |  Asao, H., et al. 2001. J Immunol. 167: 1-5. PMID: 11418623
4. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma.  |  Ueda, C., et al. 2002. Oncogene. 21: 368-76. PMID: 11821949
5. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.  |  Kasaian, MT., et al. 2002. Immunity. 16: 559-69. PMID: 11970879
6. Interleukin-21 is a growth and survival factor for human myeloma cells.  |  Brenne, AT., et al. 2002. Blood. 99: 3756-62. PMID: 11986233
7. The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.  |  Habib, T., et al. 2002. Biochemistry. 41: 8725-31. PMID: 12093291

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-21R Antibody (H-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-21R Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-21R Antibody (H-11) Specifications

Alternate Product Name: IL-21R

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 473-509

Epitope Target: IL-21R

Epitope Species: human

Product Reactivity/Detection: IL-21R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IL-21R Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin