IL-1RI Antibody (102): sc-66054
- IL-1RI Antibody (102) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against the extracellular domain of IL-1 receptor of human origin
- recommended for detection of Interleukin 1 receptor type 1 of human origin by IF and IHC(P)
- See IL-1RI (H-8): sc-393998 for IL-1RI antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-1RI Antibody (102). This work is in progress.
IL-1RI Antibody (102) is a mouse monoclonal IgG2a light chain antibody that detects IL-1RI in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). IL-1RI, or Interleukin-1 receptor type I, plays a crucial role in mediating the effects of interleukin-1, a key cytokine involved in inflammatory responses. IL-1RI is primarily located on the surface of various immune and non-immune cells, including macrophages and fibroblasts, which is significant because IL-1RI expression is essential for the initiation of pro-inflammatory signaling pathways. Upon binding with IL-1α and IL-1β ligands, IL-1RI activates intracellular signaling cascades that lead to the production of additional inflammatory mediators, thus amplifying the immune response. IL-1RI presence on a wide range of cell types underscores IL-1RI importance in both local and systemic inflammatory processes, making IL-1RI a critical target for therapeutic interventions in diseases characterized by excessive inflammation. Anti-IL-1RI antibody (102) serves as an invaluable tool for researchers studying the intricate roles of interleukin-1 signaling in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-1RI Antibody (102) References:
- IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice. | Parker, LC., et al. 2002. Br J Pharmacol. 136: 312-20. PMID: 12010781
- Interleukin-1 (IL-1alpha and IL-1beta) and its receptors (IL-1RI, IL-1RII, and IL-1Ra) in prostate carcinoma. | Ricote, M., et al. 2004. Cancer. 100: 1388-96. PMID: 15042672
- Type I IL-1 receptor (IL-1RI) as potential new therapeutic target for bronchial asthma. | Lee, JH., et al. 2010. Mediators Inflamm. 2010: 567351. PMID: 20671916
- Hippocampal distribution of IL-1β and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat. | Álvarez-Croda, DM., et al. 2016. An Acad Bras Cienc. 88 Suppl 1: 653-63. PMID: 27168372
- TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism. | He, X., et al. 2016. Sci Rep. 6: 31663. PMID: 27526865
- Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis. | Sha, Y. and Markovic-Plese, S. 2016. Front Immunol. 7: 543. PMID: 27965670
- Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection. | Shourian, M., et al. 2017. Front Immunol. 8: 1987. PMID: 29403476
- Glycan-mediated functional assembly of IL-1RI: structural insights into completion of the current description for immune response. | Azimzadeh Irani, M. and Ejtehadi, MR. 2022. J Biomol Struct Dyn. 40: 2575-2585. PMID: 33124956
- Structure-based Development of Human Interleukin-1β-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. | Kuo, WC., et al. 2021. J Mol Biol. 433: 166766. PMID: 33359099
- Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function. | Kim, DH., et al. 2021. Immune Netw. 21: e33. PMID: 34796037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-1RI Antibody (102) | sc-66054 | 100 µg/ml | $322.00 |