IL-1RI Antibody (102): sc-66054
- IL-1RI Antibody (102) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against the extracellular domain of IL-1 receptor of human origin
- recommended for detection of Interleukin 1 receptor type 1 of human origin by IF and IHC(P)
- See IL-1RI (H-8): sc-393998 for IL-1RI antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-1RI Antibody (102). This work is in progress.
IL-1RI Antibody (102) is a mouse monoclonal IgG2a light chain antibody that detects IL-1RI in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). IL-1RI, or Interleukin-1 receptor type I, plays a crucial role in mediating the effects of interleukin-1, a key cytokine involved in inflammatory responses. IL-1RI is primarily located on the surface of various immune and non-immune cells, including macrophages and fibroblasts, which is significant because IL-1RI expression is essential for the initiation of pro-inflammatory signaling pathways. Upon binding with IL-1α and IL-1β ligands, IL-1RI activates intracellular signaling cascades that lead to the production of additional inflammatory mediators, thus amplifying the immune response. IL-1RI presence on a wide range of cell types underscores IL-1RI importance in both local and systemic inflammatory processes, making IL-1RI a critical target for therapeutic interventions in diseases characterized by excessive inflammation. Anti-IL-1RI antibody (102) serves as an invaluable tool for researchers studying the intricate roles of interleukin-1 signaling in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-1RI Antibody (102) | sc-66054 | 100 µg/ml | $316.00 |