IL-1ra Antibody (A-11): sc-376094

IL-1ra Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-1ra of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IL-1ra (A-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-1ra plays a crucial role in modulating immune response by acting as a natural antagonist to pro-inflammatory cytokines IL-1α and IL-1β, which promote inflammation and immune activation. By binding to the same receptors as IL-1α and IL-1β, IL-1ra effectively inhibits their activity, preventing excessive inflammatory responses that can lead to tissue damage and chronic inflammatory diseases. This regulatory function is particularly important in conditions such as rheumatoid arthritis, where IL-1 overproduction can exacerbate joint inflammation and destruction. Additionally, IL-1ra exists in four isoforms due to alternative splicing, which may have distinct regulatory roles in various physiological and pathological contexts. IL-1ra′s ability to modulate immune responses makes this protein a significant target for therapeutic interventions aimed at controlling inflammation and autoimmunity.

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IL-1ra Antibody (A-11) References:

1. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein.  |  Carter, DB., et al. 1990. Nature. 344: 633-8. PMID: 2139180
2. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.  |  March, CJ., et al. Nature. 315: 641-7. PMID: 2989698
3. Interleukin-1Ra (Il-1Ra) and serum cortisol level relationship in horse as dynamic adaptive response during physical exercise.  |  Arfuso, F., et al. 2022. Vet Immunol Immunopathol. 243: 110368. PMID: 34922262
4. Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.  |  Motyka, NI., et al. 2022. Infect Immun. 90: e0063721. PMID: 35191758
5. Combination of Lidocaine and IL-1Ra Is Effective at Reducing Degradation of Porcine Cartilage Explants.  |  Buchanan, MW., et al. 2022. Am J Sports Med. 50: 1997-2006. PMID: 35482438
6. IL-1Ra gene transfer potentiates BMP2-mediated bone healing by redirecting osteogenesis toward endochondral ossification.  |  Panos, JA., et al. 2023. Mol Ther. 31: 420-434. PMID: 36245128
7. IL-1ra loaded chondroitin sulfate-functionalized microspheres for minimally invasive treatment of intervertebral disc degeneration.  |  Hong, Y., et al. 2024. Acta Biomater. 185: 336-349. PMID: 38969077
8. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.  |  Auron, PE., et al. 1984. Proc Natl Acad Sci U S A. 81: 7907-11. PMID: 6083565
9. Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation.  |  Zúñiga-Pflücker, JC., et al. 1995. Science. 268: 1906-9. PMID: 7541554
10. Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor.  |  Sadouk, MB., et al. 1995. Lab Invest. 73: 347-55. PMID: 7564267
11. IL-4 expression in human T cells is selectively inhibited by IL-1 alpha and IL-1 beta.  |  Sandborg, CI., et al. 1995. J Immunol. 155: 5206-12. PMID: 7594531
12. Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts.  |  Lonnemann, G., et al. 1995. Kidney Int. 47: 837-44. PMID: 7752582

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-1ra Antibody (A-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-1ra Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-1ra Antibody (A-11) Specifications

Alternate Product Name: Interleukin 1 receptor antagonist

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 17-53

Epitope Target: IL-1ra

Epitope Species: human

Product Reactivity/Detection: IL-1ra

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IL-1ra Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin