IL-1F7 Antibody (6A6): sc-517072
- IL-1F7 Antibody (6A6) is a mouse monoclonal IgG1 κ IL-1F7 antibody provided at 100 µg/ml
- raised against amino acids 1-218 representing full length IL-1F7 of human origin
- recommended for detection of IL-1F7 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-1F7 Antibody (6A6). This work is in progress.
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IL-1F7 Antibody (6A6) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-1F7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). IL-1F7 (6A6) antibody is available as the non-conjugated form. IL-1F7 protein, also known as IL-1zeta, IL-1 homolog 4 (IL-1H4), or IL-1 related protein 1 (IL-1rp1), is a member of the IL-1 superfamily, which plays a crucial role in immune response regulation. This secreted ligand is primarily expressed in the cytoplasm of peripheral monocytic cells, where IL-1F7 localizes to the inner surface of the plasma membrane and the nuclear membrane, indicating potential involvement in immune modulation. Notably, IL-1F7 has five isoforms resulting from alternative splicing, designated IL-1F7a through IL-1F7e, with isoform b being the mature functional form that interacts with the IL-18 receptor alpha chain and the IL-18 binding protein, acting as an antagonist to IL-18. The structural diversity among these isoforms, particularly the distinct N-terminus of isoform a and the truncated forms of isoforms c and d, highlights the complexity of IL-1F7′s function in immune signaling. Additionally, IL-1F7 shares 36% sequence identity with IL-1 receptor antagonist (IL-1ra), further emphasizing IL-1F7′s significance within the IL-1 superfamily and potential implications in therapeutic applications targeting inflammatory diseases.
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IL-1F7 Antibody (6A6) References:
- A sequence-based map of the nine genes of the human interleukin-1 cluster. | Nicklin, MJ., et al. 2002. Genomics. 79: 718-25. PMID: 11991722
- Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. | Kumar, S., et al. 2002. Cytokine. 18: 61-71. PMID: 12096920
- A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. | Bufler, P., et al. 2002. Proc Natl Acad Sci U S A. 99: 13723-8. PMID: 12381835
- The IL-1 family and inflammatory diseases. | Dinarello, CA. 2002. Clin Exp Rheumatol. 20: S1-13. PMID: 14989423
- Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide. | Bufler, P., et al. 2004. Biochem J. 381: 503-10. PMID: 15046617
- Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. | Dinarello, CA. 2006. Am J Clin Nutr. 83: 447S-455S. PMID: 16470011
- Association between the interleukin-1 family gene cluster and psoriatic arthritis. | Rahman, P., et al. 2006. Arthritis Rheum. 54: 2321-5. PMID: 16918024
- Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor. | Lewis, EC. and Dinarello, CA. 2006. Proc Natl Acad Sci U S A. 103: 16852-7. PMID: 17075045
- IL-18 in autoimmunity: review. | Boraschi, D. and Dinarello, CA. 2006. Eur Cytokine Netw. 17: 224-52. PMID: 17353157
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-1F7 Antibody (6A6) | sc-517072 | 100 µg/ml | $322.00 |