IL-1 beta/IL1B Antibody (E-12): sc-515787

IL-1β Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects interleukin-1β (IL-1β) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-1β is a pivotal cytokine that plays a crucial role in mediating inflammatory responses and is primarily produced by activated macrophages, although other cell types, including fibroblasts and endothelial cells, can also secrete IL-1β. Anti-IL-1β antibody (E-12) recognizes both the inactive precursor, pro-IL-1β, and the active form generated through caspase-1 cleavage. This post-translational modification is essential because active IL-1β initiates and propagates inflammatory signals, making IL-1β a key player in various immune responses. IL-1β dysregulation has been linked to numerous inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, highlighting IL-1β importance in both health and disease. IL-1β monoclonal antibody (E-12) serves as an invaluable tool for researchers studying inflammation and immune regulation mechanisms, providing insights into potential therapeutic targets for inflammatory disorders.

The preferred IL-1 beta/IL1B antibody is IL-1 beta/IL1B Antibody (B122): sc-12742.