IL-1 alpha Antibody (5G3): sc-130325

IL-1α Antibody (5G3) is a mouse monoclonal IgG1 antibody that detects interleukin-1α (IL-1α) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. IL-1α monoclonal antibody (5G3) recognizes a pivotal cytokine that plays a crucial role in mediating inflammatory responses and regulating immune functions. IL-1α is primarily produced by activated macrophages and is involved in various physiological processes, including the activation of T and B lymphocytes, as well as natural killer (NK) cells. IL-1α is secreted and can be found in the extracellular space, where binding to the interleukin-1 receptor triggers a cascade of signaling events that lead to the production of other pro-inflammatory cytokines. Anti-IL-1α antibody (5G3) helps researchers study immune responses, as IL-1α not only promotes inflammation but also influences the differentiation of immune cells, thereby shaping the overall immune landscape. Dysregulation of IL-1α has been implicated in several chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, highlighting IL-1α′s significance as a therapeutic target. IL-1α (5G3) antibody serves as an essential tool for researchers studying the intricate roles of this cytokine in health and disease.

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IL-1 alpha Antibody (5G3) References:

1. IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses.  |  Nambu, A., et al. 2006. Int Immunol. 18: 701-12. PMID: 16569679
2. IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.  |  Botelho, FM., et al. 2011. PLoS One. 6: e28457. PMID: 22163019
3. The epithelial danger signal IL-1α is a potent activator of fibroblasts and reactivator of intestinal inflammation.  |  Scarpa, M., et al. 2015. Am J Pathol. 185: 1624-37. PMID: 25864926
4. Neutralization of both IL-1α/IL-1β plays a major role in suppressing combined cigarette smoke/virus-induced pulmonary inflammation in mice.  |  Bucher, H., et al. 2017. Pulm Pharmacol Ther. 44: 96-105. PMID: 28315490
5. Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.  |  Gurung, P., et al. 2017. Immunity. 46: 635-648. PMID: 28410990
6. Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.  |  Ren, X., et al. 2017. Nat Commun. 8: 810. PMID: 28993621
7. Lipoprotein apheresis downregulates IL-1α, IL-6 and TNF-α mRNA expression in severe dyslipidaemia.  |  Stefanutti, C., et al. 2017. Atheroscler Suppl. 30: 200-208. PMID: 29096839
8. Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin.  |  Abu-Elsaad, N. and El-Karef, A. 2019. Pharmacol Rep. 71: 688-694. PMID: 31207429
9. Integrin α4β1 is required for IL-1α- and Nrf2-dependent, Cox-2 induction in fibroblasts, supporting a mechanism that suppresses α-SMA expression.  |  Zheng, R., et al. 2021. Wound Repair Regen. 29: 597-601. PMID: 34046979
10. Correction: IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma.  |  Singh, S., et al. 2024. J Immunol. 212: 500. PMID: 38088809

The preferred IL-1α antibody is IL-1α Antibody (G-10): sc-271618.