IL-18Rβ Antibody (48986): sc-80050

IL-18Rβ Antibody (48986) is a mouse monoclonal IgG2b antibody that detects IL-18R beta protein of human origin by western blotting (WB) and flow cytometry (FCM). Anti-IL-18R beta antibody (48986) is available as the non-conjugated format. The interleukin-18 receptor (IL-18R) plays a crucial role in the immune response by mediating the effects of interleukin-18, a cytokine that is pivotal for the production of interferon-gamma (IFN-γ) and the enhancement of natural killer (NK) cell cytotoxicity. IL-18R is a type I membrane protein found in various tissues, including the lung, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, while notably absent from the brain, skeletal muscle, pancreas, and kidney. The interaction between IL-18 and IL-18R triggers the activation of the NFκB signaling pathway, which is essential for the transcription of genes involved in inflammatory responses. IL-18R is composed of two subunits: IL-18Rα, which serves as the ligand-binding chain, and IL-18Rβ, which functions as the signal-transduction chain. Understanding the structure and function of IL-18R is vital, as IL-18R not only facilitates immune responses but also has implications in various diseases, including cancer and autoimmune disorders.

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IL-18Rβ Antibody (48986) References:

1. Interleukin-18 is expressed in rat testis and may promote germ cell growth.  |  Strand, ML., et al. 2005. Mol Cell Endocrinol. 240: 64-73. PMID: 16002206
2. Enhanced expression of interleukin-18 receptor alpha chain by CD4+ T cells in sarcoidosis.  |  Zhou, Y., et al. 2005. Chest. 128: 2497-503. PMID: 16236915
3. IL-18 receptor expression on epithelial cells is upregulated by TNF alpha.  |  Krásná, E., et al. 2005. Inflammation. 29: 33-7. PMID: 16502344
4. Purification and characterization of the human interleukin-18 receptor.  |  Torigoe, K., et al. 1997. J Biol Chem. 272: 25737-42. PMID: 9325300
5. Monoclonal antibodies specific for the IL-18 receptor.  |  Vermot-Desroches, C., et al. 2005. Cell Immunol. 236: 101-4. PMID: 16157318
6. Role of interleukin-18 and its receptor in hepatocellular carcinoma associated with hepatitis C virus infection.  |  Asakawa, M., et al. 2006. Int J Cancer. 118: 564-70. PMID: 16108033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-18Rβ Antibody (48986) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-18Rβ Antibody (48986) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-18Rβ Antibody (48986) Specifications

Alternate Product Name: IL-18Rβ

Product Clone Name: 48986

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: IL-18Rβ

Epitope Species: human

Product Reactivity/Detection: IL-18Rβ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, FCM

Vialing Information: Each vial contains 50 µg IgG_2b in 0.5 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IL-18Rβ Antibody (48986): N/A