IL-18R Antibody (DB08): sc-80051

IL-18R Antibody (DB08) is a rat monoclonal IgG2a antibody that detects IL-18R in mouse and rat samples through western blotting (WB). IL-18R, or Interleukin-18 receptor, plays a crucial role in the immune response by mediating the effects of IL-18, a cytokine that stimulates the production of interferon-gamma (IFN-γ) and enhances the cytotoxic activity of natural killer (NK) cells. IL-18R is vital for proper immune system functioning, as IL-18R facilitates NFκB activation upon binding with IL-18, leading to transcription of genes involved in inflammation and immune responses. IL-18R is predominantly located on type I membrane proteins found in various tissues, including the lung, spleen, liver, and heart, but is notably absent in the brain, skeletal muscle, pancreas, and kidney. IL-18R consists of two subunits: IL-18Rα, which serves as the ligand-binding chain, and IL-18Rβ, which functions as the signal-transduction chain. The interaction between IL-18 and IL-18R is essential for immune response regulation, making IL-18R a significant target for research in immunology and potential therapeutic interventions. Anti-IL-18R antibody (DB08) is an invaluable tool for researchers aiming to explore the dynamics of immune signaling pathways and the role of IL-18 in various physiological and pathological conditions.