IL-18BP Antibody (MM0379-10G36): sc-517545
- IL-18BP Antibody (MM0379-10G36) is a mouse monoclonal IgG1 IL-18BP antibody provided at 100 µg/ml
- raised against recombinant IL-18BP of human origin
- recommended for detection of IL-18BP of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-18BP Antibody (MM0379-10G36). This work is in progress.
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IL-18BP Antibody (MM0379-10G36) is a mouse monoclonal IgG1 antibody that detects IL-18BP protein of human origin by western blotting (WB). Anti-IL-18BP antibody (MM0379-10G36) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. IL-18BP, or Interleukin 18 binding protein, plays a crucial role in modulating the immune response by inhibiting IL-18 activity, a pro-inflammatory cytokine that enhances interferon-gamma (IFN-γ) production from T lymphocytes and boosts natural killer (NK) cell activity. IL-18BP is primarily located in the extracellular space, where IL-18BP binds to IL-18, preventing IL-18 from interacting with its receptor and thereby regulating the Th1 immune response. This inhibition is particularly significant in conditions such as fulminant viral hepatitis, where excessive Th1 activity can lead to tissue damage. Understanding IL-18BP function and location helps researchers better appreciate IL-18BP′s role in immune regulation and potential as a therapeutic target in inflammatory diseases.
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IL-18BP Antibody (MM0379-10G36) References:
- Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. | Novick, D., et al. 1999. Immunity. 10: 127-36. PMID: 10023777
- Cloning of a new cytokine that induces IFN-gamma production by T cells. | Okamura, H., et al. 1995. Nature. 378: 88-91. PMID: 7477296
- The interleukin-1 family: 10 years of discovery. | Dinarello, CA. 1994. FASEB J. 8: 1314-25. PMID: 8001745
- Purification of a factor which provides a costimulatory signal for gamma interferon production. | Nakamura, K., et al. 1993. Infect Immun. 61: 64-70. PMID: 8093360
- A newly defined interleukin-1? | Bazan, JF., et al. 1996. Nature. 379: 591. PMID: 8628393
- Overview of interleukin-18: more than an interferon-gamma inducing factor. | Dinarello, CA., et al. 1998. J Leukoc Biol. 63: 658-64. PMID: 9620656
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-18BP Antibody (MM0379-10G36) | sc-517545 | 100 µg/ml | $316.00 |