IL-17E Antibody (4H194): sc-71342
- IL-17E Antibody (4H194) is a mouse monoclonal IgG2b provided at 100 µg/ml
- raised against amino acids 115-132 of IL-17E of human origin
- recommended for detection of IL-17E of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-17E Antibody (4H194). This work is in progress.
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IL-17E Antibody (4H194) is a mouse monoclonal IgG2b antibody that detects Interleukin 17E (IL-17E) in mouse, rat, and human samples through western blotting (WB). IL-17E is a crucial proinflammatory cytokine produced primarily by activated T cells, playing a significant role in mediating immune responses and inflammation. This cytokine is secreted as a disulfide-linked homodimeric glycoprotein, which is essential for its biological activity. IL-17E interacts with IL-17 receptor homolog 1 (EV127/IL-17BR), leading to the activation of NF-kB signaling pathway and subsequent production of proinflammatory chemokines such as IL-8. IL-17E contributes to catabolic effects on human articular cartilage, highlighting a potential role in inflammatory diseases affecting joint health. IL-17E shows low mRNA expression levels in various peripheral tissues, indicating specific involvement in localized inflammatory responses. Anti-IL-17E antibody (4H194) serves as an invaluable tool for researchers studying complex mechanisms of immune regulation and inflammation, providing insights into therapeutic potential of targeting this unique cytokine in various diseases.
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IL-17E Antibody (4H194) References:
- IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. | Lee, J., et al. 2001. J Biol Chem. 276: 1660-4. PMID: 11058597
- Interleukin-17 family and IL-17 receptors. | Moseley, TA., et al. 2003. Cytokine Growth Factor Rev. 14: 155-74. PMID: 12651226
- Virulizin induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors. | Benatar, T., et al. 2008. Cancer Immunol Immunother. 57: 1757-69. PMID: 18351336
- IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo. | Benatar, T., et al. 2010. Cancer Immunol Immunother. 59: 805-17. PMID: 20012860
- IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. | Furuta, S., et al. 2011. Sci Transl Med. 3: 78ra31. PMID: 21490275
- Expression of IL-17A, E, and F and their receptors in non-small-cell lung cancer. | Huang, Q., et al. 2018. J Biol Regul Homeost Agents. 32: 1105-1116. PMID: 30334403
- Biological Properties and the Role of IL-25 in Disease Pathogenesis. | Liu, Y., et al. 2018. J Immunol Res. 2018: 6519465. PMID: 30345318
- The potential role and status of IL-17 family cytokines in breast cancer. | Song, X., et al. 2021. Int Immunopharmacol. 95: 107544. PMID: 33740640
- Gastric Th17 Cells Specific for H+/K+-ATPase and Serum IL-17 Signature in Gastric Autoimmunity. | Della Bella, C., et al. 2022. Front Immunol. 13: 952674. PMID: 35911678
- Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activity. | Hu, X., et al. 2024. J Immunother Cancer. 12: PMID: 38519059
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-17E Antibody (4H194) | sc-71342 | 100 µg/ml | $316.00 |