IL-16 Antibody (D-2): sc-374605
- IL-16 Antibody (D-2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 502-631 mapping at the C-terminus of IL-16 of human origin
- recommended for detection of IL-16 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for IL-16 Antibody (D-2) for WB applications. This reagent is now offered in a bundle with IL-16 Antibody (D-2) (see ordering information below).
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IL-16 Antibody (D-2) is a mouse monoclonal IgG2b antibody that detects interleukin-16 (IL-16) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-16 functions as a crucial cytokine known for its role as a lymphocyte chemoattractant factor, particularly for CD4+ T lymphocytes, which are essential for orchestrating immune responses. Anti-IL-16 antibody (D-2) enables research into IL-16′s ability to mediate immune cell recruitment to inflammation sites, particularly in allergic reactions, where IL-16 is secreted by activated eosinophils alongside other cytokines like RANTES. Upon binding to CD4 receptor, IL-16 triggers intracellular signaling events, including protein kinase C (PKC) pathway activation, leading to physiological changes in target cells. This mechanism is vital for understanding allergic inflammation and immune regulation processes, making IL-16 a significant target for research in immunology and therapeutic interventions. IL-16 monoclonal antibody (D-2) provides a reliable tool for studying these processes, enabling researchers to explore immune cell interactions and cytokine roles in health and disease.
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IL-16 Antibody (D-2) References:
- IL-15 and IL-16 overexpression in cutaneous T-cell lymphomas: stage-dependent increase in mycosis fungoides progression. | Asadullah, K., et al. 2000. Exp Dermatol. 9: 248-51. PMID: 10949545
- IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. | Ghigo, E., et al. 2010. PLoS One. 5: e13561. PMID: 21042409
- Association between serum IL-16 levels and the degree of sensitization in patients with atopic dermatitis. | Nagy, G., et al. 2011. Int Arch Allergy Immunol. 156: 69-74. PMID: 21447961
- Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia. | Ahn, DS., et al. 2014. Mucosal Immunol. 7: 1366-74. PMID: 24736233
- Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome. | Landi, A., et al. 2016. Cytokine. 78: 27-36. PMID: 26615570
- Cord Blood IL-16 Is Associated with 3-Year Neurodevelopmental Outcomes in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy. | Ahearne, CE., et al. 2017. Dev Neurosci. 39: 59-65. PMID: 28490023
- IL-16 processing in sentinel node regulatory T cells is a factor in bladder cancer immunity. | Krantz, D., et al. 2020. Scand J Immunol. 92: e12926. PMID: 32862475
- Zinc Aspartate Induces IL-16 Secretion and Apoptosis in Human T Cells. | Reinhold, D., et al. 2021. Biomedicines. 9: PMID: 33804583
- Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells. | Hridi, SU., et al. 2021. Biology (Basel). 10: PMID: 34071825
- Lymphoma cell-driven IL-16 is expressed in activated B-cell-like diffuse large B-cell lymphomas and regulates the pro-tumor microenvironment. | Guan, X., et al. 2025. Haematologica. 110: 425-438. PMID: 39323416
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-16 Antibody (D-2) | sc-374605 | 200 µg/ml | $322.00 | |||
IL-16 Antibody (D-2): m-IgG2b BP-HRP Bundle | sc-548583 | 200 µg Ab; 10 µg BP | $361.00 |