IL-15Rα Antibody (G-7): sc-271366

IL-15Rα Antibody (G-7) is a mouse monoclonal IgG1 antibody that detects IL-15Rα in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-15Rα plays a crucial role in the immune system by serving as a receptor for interleukin-15, a cytokine vital for the proliferation and activation of T cells and natural killer (NK) cells. IL-15Rα (G-7) antibody recognizes IL-15Rα on the surface of immune cells, which is essential for their responsiveness to IL-15, thereby influencing the overall immune response. IL-15Rα monoclonal antibody (G-7) targets proteins primarily located on the membranes of immune cells, including T cells and NK cells, which underscores its importance in mediating the effects of IL-15 in these cells. The interaction between IL-15 and its receptor is critical for the development and maintenance of memory T cells, which are essential for long-term immunity. Furthermore, IL-15Rα can also exist in a soluble form, which may play a role in modulating immune responses and could have implications in various diseases, including cancer and autoimmune disorders. Anti-IL-15Rα antibody (G-7) serves as an invaluable tool for researchers studying the dynamics of immune cell activation and the therapeutic potential of targeting the IL-15/IL-15Rα axis in immunological research.

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IL-15Rα Antibody (G-7) References:

1. Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.  |  Mortier, E., et al. 2006. J Biol Chem. 281: 1612-9. PMID: 16284400
2. Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent.  |  Guo, Y., et al. 2017. Cytokine Growth Factor Rev. 38: 10-21. PMID: 28888485
3. Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma.  |  Shirley, SA., et al. 2020. Cancers (Basel). 12: PMID: 33096755
4. IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models.  |  Guo, S., et al. 2020. Front Immunol. 11: 614667. PMID: 33628206
5. Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment.  |  Zhang, W., et al. 2022. Cancer Commun (Lond). 42: 536-557. PMID: 35615815
6. Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer.  |  Kurz, E., et al. 2022. Cancer Cell. 40: 720-737.e5. PMID: 35660135
7. Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo.  |  Silvestre, RN., et al. 2023. Front Immunol. 14: 1226518. PMID: 37818365
8. First-in-human phase I/Ib study of NIZ985, a recombinant heterodimer of IL-15 and IL-15Rα, as a single agent and in combination with spartalizumab in patients with advanced and metastatic solid tumors.  |  Leidner, R., et al. 2023. J Immunother Cancer. 11: PMID: 37907221
9. IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion.  |  Li, J., et al. 2024. Mol Cancer Ther. 23: 1305-1316. PMID: 38739434
10. Efficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder.  |  Mai, Q., et al. 2024. Exp Hematol Oncol. 13: 85. PMID: 39160631

The preferred IL-15Rα antibody is IL-15Rα Antibody (G-3): sc-374023.