IL-15 Antibody (YNR-HIL15): sc-73311
- IL-15 Antibody (YNR-HIL15) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant IL-15 of human origin
- recommended for detection of IL-15 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-15 Antibody (YNR-HIL15). This work is in progress.
QUICK LINKS
SEE ALSO...
IL-15 Antibody (YNR-HIL15) is a mouse monoclonal IgG1 antibody that detects interleukin-15 (IL-15) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). IL-15 is a crucial cytokine that plays a significant role in the immune response by stimulating the proliferation of T cells and natural killer (NK) cells, as well as enhancing B cell expansion and antibody production. Notably, IL-15 is produced by non-lymphoid cells such as macrophages, epithelial cells, muscle tissue, and the placenta, distinguishing IL-15 from IL-2, which is primarily produced by lymphocytes. The unique production profile of IL-15 allows for a broader range of immune modulation, particularly in tissue repair and inflammation. Additionally, IL-15 has been shown to act as a chemoattractant for human blood T lymphocytes and can induce lymphokine-activated killer (LAK) activity in NK cells, further emphasizing IL-15′s role in enhancing immune responses. IL-15 consists of a 162 amino acid precursor that undergoes cleavage to yield its mature form, and IL-15 shares the β signaling subunit of the IL-2 receptor, indicating a complex interplay with other cytokines in the immune system. Anti-IL-15 antibody (YNR-HIL15) is an essential tool for researchers studying immune responses, cytokine signaling, and the therapeutic potential of IL-15 in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-15 Antibody (YNR-HIL15) References:
- The potential and promise of IL-15 in immuno-oncogenic therapies. | Robinson, TO. and Schluns, KS. 2017. Immunol Lett. 190: 159-168. PMID: 28823521
- Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent. | Guo, Y., et al. 2017. Cytokine Growth Factor Rev. 38: 10-21. PMID: 28888485
- Rationale for IL-15 superagonists in cancer immunotherapy. | Knudson, KM., et al. 2020. Expert Opin Biol Ther. 20: 705-709. PMID: 32159390
- Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy. | Yang, Y. and Lundqvist, A. 2020. Cancers (Basel). 12: PMID: 33266177
- Heterodimeric IL-15 in Cancer Immunotherapy. | Bergamaschi, C., et al. 2021. Cancers (Basel). 13: PMID: 33671252
- A very long-acting IL-15: implications for the immunotherapy of cancer. | Hangasky, JA., et al. 2022. J Immunother Cancer. 10: PMID: 35101947
- IL-15/IL-15Rα in SJS/TEN: Relevant Expression of IL15 and IL15RA in Affected Skin. | Bellón, T., et al. 2022. Biomedicines. 10: PMID: 36009415
- IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer. | Wong, JL., et al. 2023. Proc Natl Acad Sci U S A. 120: e2306782120. PMID: 37607227
- IL-15 and N-803 for HIV Cure Approaches. | Howard, JN. and Bosque, A. 2023. Viruses. 15: PMID: 37766318
- IL-15 in T-Cell Responses and Immunopathogenesis. | Lee, H., et al. 2024. Immune Netw. 24: e11. PMID: 38455459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-15 Antibody (YNR-HIL15) | sc-73311 | 100 µg/ml | $322.00 |