IL-12B p40 Antibody (C17.8): sc-57258
- IL-12B p40 Antibody (C17.8) is a rat monoclonal IgG2a, cited in 9 publications, provided at 200 µg/ml
- raised against full length IL-12B p40 of mouse origin
- recommended for detection of IL-12B p40 of mouse origin by WB, IP, IF, IHC(P) and ELISA; also recommended for detection of IL-12/IL-23 p40 subunit (monomer, homodimer and heterodimer IL-12 p35/p40 or IL-23 p19/p40)
- also provided azide-free for neutralization studies, sc-57258 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-12B p40 Antibody (C17.8). This work is in progress.
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IL-12B p40 Antibody (C17.8) is a rat monoclonal IgG2a antibody that detects IL-12B p40 in mouse samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IL-12B p40 plays a crucial role in the immune response as a subunit of the heterodimeric cytokine interleukin-12 (IL-12), which is essential for the differentiation of naive CD4(+) T cells into type 1 helper T cells that produce interferon-γ (IFN-γ). This process is vital for the activation of T and natural killer (NK) cells, which are key players in the body′s defense against infections and tumors. Additionally, IL-12B p40 can combine with p19 to form interleukin-23 (IL-23), a cytokine that shares some functional properties with IL-12, including the activation of the transcription factor Stat4 and the promotion of IFN-γ production. The ability of IL-12B p40 to influence both IL-12 and IL-23 pathways highlights its importance in regulating immune responses and maintaining immune homeostasis, making anti-IL-12B p40 antibody (C17.8) a valuable tool for researchers studying cytokine signaling and immune function in mouse models.
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IL-12B p40 Antibody (C17.8) References:
- The IL12B gene does not confer susceptibility to coeliac disease. | Louka, AS., et al. 2002. Tissue Antigens. 59: 70-2. PMID: 11972887
- Polymorphism in the 3' UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy. | Zafra, G., et al. 2007. Microbes Infect. 9: 1049-52. PMID: 17644387
- The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis. | Begovich, AB., et al. 2007. Hum Immunol. 68: 934-7. PMID: 18082575
- Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. | Nair, RP., et al. 2008. J Invest Dermatol. 128: 1653-61. PMID: 18219280
- Contribution of IL12A and IL12B polymorphisms to the risk of cervical cancer. | Roszak, A., et al. 2012. Pathol Oncol Res. 18: 997-1002. PMID: 22614250
- IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. | Kobayashi, T., et al. 2012. J Immunol. 189: 1792-9. PMID: 22786766
- Polymorphisms of the IL12B, IL1B, and TNFA genes and susceptibility to asthma. | Padrón-Morales, J., et al. 2013. J Investig Allergol Clin Immunol. 23: 487-94. PMID: 24654313
- Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet's disease: A meta-analysis. | Xu, Y., et al. 2016. Z Rheumatol. 75: 932-938. PMID: 26800664
- Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis. | van den Reek, JMPA., et al. 2017. Br J Dermatol. 176: 1288-1296. PMID: 27564082
- IL18 Polymorphism and Periodontitis Susceptibility, Regardless of IL12B, MMP9, and Smoking Habits. | Tsuneto, PY., et al. 2019. Mediators Inflamm. 2019: 9585964. PMID: 31065235
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-12B p40 Antibody (C17.8) | sc-57258 | 200 µg/ml | $322.00 | |||
IL-12B p40 Antibody (C17.8) L | sc-57258 L | 200 µg/0.1 ml | $322.00 |