IL-12 Antibody (JJ07): sc-74147
- IL-12 Antibody (JJ07) is a mouse monoclonal IgG1 IL-12 antibody, cited in 5 publications, provided at 50 µg/0.5 ml
- raised against full length recombinant IL-12 of human origin
- recommended for detection of IL-12 of human origin by WB, IF, IHC(P) and ELISA; non cross-reactive with IL-23 or IL-12 p40
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-12 Antibody (JJ07). This work is in progress.
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IL-12 Antibody (JJ07) is a mouse monoclonal IgG1 antibody that detects IL-12 protein of human origin by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-12 antibody (JJ07) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical cytokine. IL-12, also known as Interleukin 12, plays a pivotal role in the immune response by promoting the differentiation of naive T cells into Th1 cells, which are essential for the production of interferon-gamma and the activation of cytotoxic T lymphocytes. This function is crucial for the body′s defense against intracellular pathogens and tumors, making IL-12 a key player in both innate and adaptive immunity. IL-12 is produced by antigen-presenting cells, such as dendritic cells and macrophages, in response to infection, highlighting its importance in the early stages of immune activation. IL-12′s ability to enhance the cytotoxic activity of natural killer cells and stimulate the production of other pro-inflammatory cytokines underscores its significance in orchestrating a robust immune response. With diverse roles in immune regulation, IL-12 continues to be a focus of research, particularly in the context of immunotherapy and vaccine development.
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IL-12 Antibody (JJ07) References:
- Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12. | Yao, L., et al. 2000. Blood. 96: 1900-5. PMID: 10961892
- Organic dust-induced interleukin-12 production activates T- and natural killer cells. | Muller-Suur, C., et al. 2002. Eur Respir J. 20: 686-90. PMID: 12358348
- CD8+ immunoregulatory cells in the graft-versus-host reaction: CD8 T cells activate dendritic cells to secrete interleukin-12/interleukin-18 and induce T helper 1 autoantibody. | Noble, A., et al. 2003. Immunology. 109: 476-86. PMID: 12871213
- Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferon-gamma. | Yamamoto, N., et al. 2004. Microbes Infect. 6: 1241-9. PMID: 15555529
- Impact of interleukin-12, oxidative burst, and iNOS on the survival of murine fecal peritonitis. | Entleutner, M., et al. 2006. Int J Colorectal Dis. 21: 64-70. PMID: 15756596
- Assessment of interleukin-12, gamma interferon, and tumor necrosis factor alpha secretion in sera from mice fed with dietary lipids during different stages of Listeria monocytogenes infection. | Puertollano, MA., et al. 2005. Clin Diagn Lab Immunol. 12: 1098-103. PMID: 16148177
- Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response. | Gafa, V., et al. 2006. Infect Immun. 74: 1480-9. PMID: 16495518
- Interleukin-12 is reduced in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia. | Rentzos, M., et al. 2006. J Neurol Sci. 249: 110-4. PMID: 16843497
- Regulation of lipopolysaccharide-induced interleukin-12 production by activation of repressor element GA-12 through hyperactivation of the ERK pathway. | Saito, S., et al. 2006. Clin Vaccine Immunol. 13: 876-83. PMID: 16893987
- Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. | Koshiba, R., et al. 2013. Biochem Biophys Res Commun. 430: 95-100. PMID: 23154183
- Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease. | Dubinsky, MC., et al. 2013. Inflamm Bowel Dis. 19: 1662-70. PMID: 23665963
- Cytokine Gene Polymorphism Profiles in Kidney Transplant Patients - Association of +1188A/C RS3212227 SNP in the IL12B Gene Prevents Delayed Graft Function. | Perovic, V., et al. 2018. Arch Med Res. 49: 101-108. PMID: 29754746
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-12 Antibody (JJ07) | sc-74147 | 50 µg/0.5 ml | $322.00 |