IL-11 Antibody (A-9): sc-133063

IL-11 Antibody (A-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects IL-11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-IL-11 antibody (A-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Interleukin-11, or IL-11, is a pleiotropic cytokine that plays a crucial role in immune regulation and inflammation, being biologically related to other cytokines such as IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). IL-11 is primarily secreted by stromal cells and is essential for stimulating the proliferation of primitive hematopoietic progenitor cells, which is vital for maintaining healthy blood cell production. Additionally, IL-11 works in conjunction with Flt 3-L to promote the expansion of CD34+ cell populations, which are critical for hematopoiesis. Human IL-11 cDNA encodes a 199 amino acid precursor that includes a 21 amino acid hydrophobic signal peptide, which is cleaved to produce a glycosylated, biologically active form of IL-11. IL-11 exerts effects through the interleukin-11 receptor, IL-11R, composed of an IL-11 receptor-specific chain, IL-11Rα, and gp130, a common signal transducing component for several related receptors. Upon binding to IL-11R, IL-11 activates Janus tyrosine kinases JAK1 and JAK2, leading to the nuclear translocation of transcription factors Stat1 and Stat3, which are crucial for mediating the downstream effects of IL-11 signaling.

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IL-11 Antibody (A-9) References:

1. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.  |  Paul, SR., et al. 1990. Proc Natl Acad Sci U S A. 87: 7512-6. PMID: 2145578
2. Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study.  |  Wan, B., et al. 2015. Cytokine. 76: 138-143. PMID: 26276375
3. Proteolytic control of Interleukin-11 and Interleukin-6 biology.  |  Lokau, J., et al. 2017. Biochim Biophys Acta Mol Cell Res. 1864: 2105-2117. PMID: 28630024
4. Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway.  |  Ng, B., et al. 2020. Exp Mol Med. 52: 1871-1878. PMID: 33262481
5. Roles of IL-11 in the regulation of bone metabolism.  |  Han, Y., et al. 2023. Front Endocrinol (Lausanne). 14: 1290130. PMID: 38352248
6. Interleukin 11 therapy causes acute left ventricular dysfunction.  |  Sweeney, M., et al. 2024. Cardiovasc Res. 120: 2220-2235. PMID: 39383190
7. Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association.  |  Matsuda, T., et al. 1995. J Biol Chem. 270: 11037-9. PMID: 7538109
8. Interleukin (IL)-11--mediated signal transduction.  |  Yang, YC. and Yin, T. 1995. Ann N Y Acad Sci. 762: 31-40; discussion 40-1. PMID: 7545369
9. IL-11 in combination with SLF and G-CSF or GM-CSF significantly increases expansion of isolated CD34+ cell population from cord blood vs. adult bone marrow.  |  van de Ven, C., et al. 1995. Exp Hematol. 23: 1289-95. PMID: 7589284
10. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.  |  Boulton, TG., et al. 1995. Proc Natl Acad Sci U S A. 92: 6915-9. PMID: 7624343
11. Interleukin-11 (IL-11) acts as a synergistic factor for the proliferation of human myeloid leukaemic cells.  |  Lemoli, RM., et al. 1995. Br J Haematol. 91: 319-26. PMID: 8547068
12. Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.  |  Bellido, T., et al. 1996. J Clin Invest. 97: 431-7. PMID: 8567964

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-11 Antibody (A-9) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-11 Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-11 Antibody (A-9) Specifications

Alternate Product Name: Interleukin 11

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 31-199

Epitope Target: IL-11

Epitope Species: human

Product Reactivity/Detection: IL-11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for IL-11 Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin