IKIP Antibody (E-3): sc-515346

IKIP Antibody (E-3) is a mouse monoclonal IgM kappa light chain antibody that detects IKIP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IKIP antibody (E-3) is available as the non-conjugated form. IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein) plays a crucial role in cellular apoptosis and is believed to be a target for the tumor suppressor protein p53. By promoting apoptosis, IKIP (E-3) antibody helps regulate cell survival and proliferation, making IKIP significant in cancer research and therapeutic strategies. IKIP is a single-pass membrane protein that shares a common promoter with APAF1, and both proteins are induced by X irradiation, although they are transcribed in opposite directions. IKIP has four known isoforms, with three traversing the endoplasmic reticulum membrane, while isoform 4 lacks the transmembrane region, resulting in a more uniform distribution throughout the cell. IKIP expression is primarily observed in vascular endothelial cells, with isoform 4 also detected in various tissues, including the lung, kidney, spleen, thymus, and skeletal muscle, highlighting diverse functional roles in different cellular contexts.

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IKIP Antibody (E-3) References:

1. Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation.  |  Arty, IS., et al. 2000. Eur J Med Chem. 35: 449-57. PMID: 10858605
2. Translation, cultural adjustment, and validation of a measure of adaptive behavior.  |  Tombokan-Runtukahu, J. and Nitko, AJ. 1992. Res Dev Disabil. 13: 481-501. PMID: 1410714
3. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53.  |  Hofer-Warbinek, R., et al. 2004. Cell Death Differ. 11: 1317-25. PMID: 15389287
4. Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins.  |  Friedrichsen, M., et al. 2010. J Clin Endocrinol Metab. 95: 414-21. PMID: 19875481
5. Structural insights into IKKbeta inhibition by natural products staurosporine and quercetin.  |  Avila, CM., et al. 2009. Bioorg Med Chem Lett. 19: 6907-10. PMID: 19896375
6. The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy.  |  Lin, Y., et al. 2010. Expert Opin Ther Targets. 14: 45-55. PMID: 20001209
7. Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system.  |  Emmanouil, M., et al. 2009. J Immunol. 183: 7877-89. PMID: 20007573
8. Inhibition of inflammatory cytokine production from rheumatoid synovial fibroblasts by a novel IkappaB kinase inhibitor.  |  Tsuchiya, A., et al. 2010. J Pharmacol Exp Ther. 333: 236-43. PMID: 20053934
9. Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides.  |  Baima, ET., et al. 2010. J Biol Chem. 285: 13498-506. PMID: 20167598

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IKIP Antibody (E-3) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IKIP Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IKIP Antibody (E-3) Specifications

Alternate Product Name: IKIP

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 174-189

Epitope Target: IKIP

Epitope Species: human

Product Reactivity/Detection: IKIP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IKIP Antibody (E-3): P: Blocking Peptide