IκB-β Antibody (G-6): sc-74453
- IκB-β Antibody (G-6) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-359 representing full length IκB-β of mouse origin
- recommended for detection of IκB-β of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-74453 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP is the preferred secondary detection reagent for IκB-β Antibody (G-6) for WB applications. This reagent is now offered in a bundle with IκB-β Antibody (G-6) (see ordering information below).
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IκB-β Antibody (G-6) is a mouse monoclonal IgG2b antibody that detects IκB-β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IκB-β plays a crucial role in the regulation of the NF-κB signaling pathway, which is essential for controlling immune responses, inflammation, and cell survival. By sequestering NF-κB dimers in the cytoplasm, IκB-β prevents their translocation to the nucleus, thereby inhibiting the transcription of target genes involved in these processes. The importance of IκB-β extends to its involvement in various post-translational modifications, including phosphorylation, which can influence stability and the release of NF-κB. Understanding these modifications is vital, as they can affect the cellular response to stress and inflammation, making IκB-β a significant player in both normal physiology and disease states. Anti-IκB-β antibody (G-6) is an invaluable tool for researchers studying the dynamics of NF-κB signaling and its implications in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IκB-β Antibody (G-6) References:
- Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. | Venkatakrishnan, A., et al. 2000. Am J Respir Cell Mol Biol. 23: 396-403. PMID: 10970832
- Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. | Chen, Y., et al. 2004. Mol Cell Biol. 24: 3048-56. PMID: 15024091
- Phosphorylation of IkappaB-beta is necessary for neuronal survival. | Liu, L. and D'Mello, SR. 2006. J Biol Chem. 281: 1506-15. PMID: 16286457
- IκBβ attenuates angiotensin II-induced cardiovascular inflammation and fibrosis in mice. | Xu, S., et al. 2011. Hypertension. 58: 310-6. PMID: 21646597
- Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. | Song, T., et al. 2016. FASEB J. 30: 214-29. PMID: 26373801
- Overexpression of Hypo-Phosphorylated IκBβ at Ser313 Protects the Heart against Sepsis. | Wang, GQ., et al. 2016. PLoS One. 11: e0160860. PMID: 27508931
- Inhibition of IκBβ/NFκB signaling prevents LPS-induced IL1β expression without increasing apoptosis in the developing mouse lung. | McKenna, S., et al. 2017. Pediatr Res. 82: 1064-1072. PMID: 28753596
- The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction. | Shoji, S., et al. 2020. FEBS Lett. 594: 1532-1549. PMID: 32017069
- CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression. | De Dios, R., et al. 2020. Immunology. 160: 64-77. PMID: 32064589
- Distinct functional properties of IkappaB alpha and IkappaB beta. | Tran, K., et al. 1997. Mol Cell Biol. 17: 5386-99. PMID: 9271416
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IκB-β Antibody (G-6) | sc-74453 | 200 µg/ml | $322.00 | |||
IκB-β Antibody (G-6): m-IgG2b BP-HRP Bundle | sc-548460 | 200 µg Ab; 10 µg BP | $361.00 | |||
IκB-β Antibody (G-6) X | sc-74453 X | 200 µg/0.1 ml | $322.00 |