Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Immunoglobulin M (IgM) is the largest circulating antibody molecule in humans. It is the first immunoglobulin expressed by mature B cells, and it normally appears early in the course of an infection and does not reappear after further exposure. Immunoglobulins consist of two heavy chains (µ-chains) and two light chains (κ- or λ-chains), that together comprise the Fab (antigen binding) and Fc (constant) fragments. IgM normally exists as a pentamer, but occasionally as a hexamer. IgM is mainly found in serum, however, it is also important as a secretory immunoglobulin. Monovalent Fab fragments have two antigen binding sites, so they may be used to sterically cover the surface of immunoglobulins for double labeling primary antibodies from the same host species, or to block endogenous immunoglobulins on cell surfaces or in tissue sections. After binding to the primary antibody, most of the secondary antibodies will still have one open binding site, which can capture the second primary antibody from the same species. Consequently, overlapping labeling of the two antigens will occur.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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