IgM Fc region Antibody (2B9): sc-52010
- IgM Fc region Antibody (2B9) is a mouse monoclonal IgG2b provided at 100 µg/ml
- raised against IgM from human serum
- recommended for detection of Fc-region of Mu chain of IgM of human origin by WBIPELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgM Fc region Antibody (2B9). This work is in progress.
QUICK LINKS
SEE ALSO...
IgM Fc region Antibody (2B9) is a mouse monoclonal IgG2b antibody that detects Immunoglobulin M (IgM) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IgM is a crucial component of the immune system, serving as the first line of defense during an initial immune response. IgM is primarily produced by B cells and plays a vital role in identifying and neutralizing pathogens. Structurally, IgM is unique as IgM typically exists as a pentamer, which enhances IgM′s ability to bind multiple antigens simultaneously, thus increasing overall avidity. This pentameric form is essential for effective immune responses, as this form allows for rapid aggregation of pathogens and facilitates pathogen clearance from the body. The IgM Fc region is particularly important for activating the complement system, which further aids in pathogen destruction. IgM Fc region (2B9) antibody provides reliable detection and quantification of IgM, making IgM Fc region (2B9) antibody an invaluable tool for researchers studying immune responses, infectious diseases, and antibody-mediated processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IgM Fc region Antibody (2B9) References:
- The long elusive IgM Fc receptor, FcμR. | Kubagawa, H., et al. 2014. J Clin Immunol. 34 Suppl 1: S35-45. PMID: 24793544
- Unique ligand-binding property of the human IgM Fc receptor. | Honjo, K., et al. 2015. J Immunol. 194: 1975-82. PMID: 25601920
- Role of the IgM Fc Receptor in Immunity and Tolerance. | Liu, J., et al. 2019. Front Immunol. 10: 529. PMID: 30967868
- Functional Roles of the IgM Fc Receptor in the Immune System. | Kubagawa, H., et al. 2019. Front Immunol. 10: 945. PMID: 31130948
- Mapping of the binding site for FcμR in human IgM-Fc. | Nyamboya, RA., et al. 2020. Biochim Biophys Acta Proteins Proteom. 1868: 140266. PMID: 31449905
- Regulation of Humoral Immune Responses and B Cell Tolerance by the IgM Fc Receptor (FcμR). | Liu, J., et al. 2020. Adv Exp Med Biol. 1254: 75-86. PMID: 32323271
- Identification of Amino Acid Residues in Human IgM Fc Receptor (FcµR) Critical for IgM Binding. | Skopnik, CM., et al. 2020. Front Immunol. 11: 618327. PMID: 33584711
- Questioning whether IgM Fc receptor (FcµR) is expressed by innate immune cells. | Skopnik, CM., et al. 2022. Nat Commun. 13: 3951. PMID: 35817797
- Physiological and Pathophysiological Roles of IgM Fc Receptor (FcµR) Isoforms. | Kubagawa, H., et al. 2023. Int J Mol Sci. 24: PMID: 36982860
- Functions of IgM fc receptor (FcµR) related to autoimmunity. | Kubagawa, H., et al. 2024. Autoimmunity. 57: 2323563. PMID: 38465789
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgM Fc region Antibody (2B9) | sc-52010 | 100 µg/ml | $316.00 |