IgM Antibody (M11): sc-66121
- IgM Antibody (M11) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against IgM of human origin
- recommended for detection of IgM of human origin by WB, IP and ELISA
- See IgM (R1/69): sc-53347 for IgM antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgM Antibody (M11). This work is in progress.
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IgM Antibody (M11) is a mouse monoclonal IgG1 antibody that detects Immunoglobulin M (IgM) in human samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IgM is the largest circulating antibody molecule in humans, consisting of a heavy chain (µ-chain) and a light chain (κ- or λ-chain), forming a pentameric structure with ten binding sites, although steric hindrance prevents simultaneous binding at all sites. The unique structure of IgM is crucial for immune response, exhibiting high avidity due to its polymeric nature, making IgM particularly effective at activating the complement system, which is essential for opsonization and lysis of pathogens. IgM is the first immunoglobulin produced by mature B cells during an immune response, appearing early in infection, which underscores IgM′s importance in initial defense against pathogens. While primarily found in serum, the presence of the J chain allows IgM to function as a secretory immunoglobulin, contributing to mucosal immunity. The IgM chain C, which refers to the constant region of the IgM heavy chain, plays a significant role in immune regulation, further highlighting IgM′s importance in maintaining immune homeostasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IgM Antibody (M11) References:
- Monoclonal IgM autoantibody reactivity in M-IgM peripheral neuropathy. | Caudie, C. 2000. Clin Rev Allergy Immunol. 19: 7-18. PMID: 11064822
- Transplantation for IgM amyloidosis and IgM myeloma. | Gertz, MA., et al. 2009. Clin Lymphoma Myeloma. 9: 77-9. PMID: 19362980
- IgM contributes to glomerular injury in FSGS. | Strassheim, D., et al. 2013. J Am Soc Nephrol. 24: 393-406. PMID: 23393315
- Age-related aspects of human IgM(+) B cell heterogeneity. | Martin, V., et al. 2015. Ann N Y Acad Sci. 1362: 153-63. PMID: 26152370
- Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis. | Nierhaus, A., et al. 2020. Ann Intensive Care. 10: 132. PMID: 33026597
- Positive selection of IgG+ over IgM+ B cells in the germinal center reaction. | Sundling, C., et al. 2021. Immunity. 54: 988-1001.e5. PMID: 33857421
- IgM single antigen bead HLA-assay is affected by imlifidase through the cleavage of IgG but not IgM. | Runström, A., et al. 2021. Transpl Immunol. 68: 101436. PMID: 34265468
- Revisiting the spectrum of IgM-related neuropathies in a large cohort of IgM monoclonal gammopathy. | Bardel, B., et al. 2022. J Neurol. 269: 4955-4960. PMID: 35505107
- IgM+ and IgM- memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge with P. yoelii. | Brown, SL., et al. 2022. J Leukoc Biol. 112: 1115-1135. PMID: 35657097
- A Serodiagnostic IgM ELISA to Detect Acute Cytauxzoonosis. | Kao, YF., et al. 2022. Pathogens. 11: PMID: 36297239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgM Antibody (M11) | sc-66121 | 100 µg/ml | $316.00 |