IgM Antibody (A-7): sc-373781
- IgM Antibody (A-7) is a mouse monoclonal IgM κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 407-439 near the C-terminus of IgM of human origin
- recommended for detection of IgM of human origin by WB, IP, IF, IHC(P) and ELISA
- See IgM (R1/69): sc-53347 for IgM antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgM Antibody (A-7). This work is in progress.
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IgM Antibody (A-7) is a mouse monoclonal IgM antibody that detects Immunoglobulin M (IgM) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IgM is the largest circulating antibody molecule in humans, consisting of a heavy chain (µ-chain) and a light chain (κ- or λ-chain), along with five base units and ten binding sites, although IgM cannot bind all ten simultaneously due to steric hindrance. The structure of IgM is particularly important as IgM typically exists as a pentamer, allowing for high avidity and effective complement activation, which is crucial for the immune response. Additionally, IgM can form hexamers and is characterized by a polymeric nature, which enhances IgM′s ability to bind antigens and activate the complement system, making IgM a key player in the early stages of infection. While IgM is predominantly found in serum, IgM′s presence in the interstitium is minimal due to size, and IgM plays a significant role as a secretory immunoglobulin thanks to the J chain. As the first immunoglobulin expressed by mature B cells, IgM is essential for initiating the immune response, appearing early during infections and serving as a critical marker for immune system activity.
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IgM Antibody (A-7) References:
- Clinicopathological correlates of IgM paraproteinemias. | Owen, RG., et al. 2000. Clin Lymphoma. 1: 39-43; discussion 44-5. PMID: 11707811
- IgM in the airways of asthma patients. | Hol, BE., et al. 1991. Int Arch Allergy Appl Immunol. 96: 12-8. PMID: 1721608
- IgM(+) memory B cell expression predicts HIV-associated cryptococcosis status. | Subramaniam, K., et al. 2009. J Infect Dis. 200: 244-51. PMID: 19527168
- Rubella IgM detection in pregnancy. | Wunderli, W., et al. 1990. Lancet. 335: 1042-3. PMID: 1970098
- A comparative characterization of dipentameric (IgM)(2) and pentameric IgM species present in preparations of a monoclonal IgM for therapeutic use. | Tarköy, M., et al. 2010. J Pharm Biomed Anal. 51: 1084-90. PMID: 20005064
- IgM monoclonal gammopathy-associated neuropathies with different IgM specificity. | Matà, S., et al. 2011. Eur J Neurol. 18: 1067-73. PMID: 21261794
- CD22 serves as a receptor for soluble IgM. | Adachi, T., et al. 2012. Eur J Immunol. 42: 241-7. PMID: 21956693
- Hyper IgM Syndrome with low IgM and thrombocytosis: an unusual case of immunodeficiency. | Yousef, E. and Arshad Alvi, M. 2016. Eur Ann Allergy Clin Immunol. 48: 194-6. PMID: 27608476
- Removal of IgM from serum by ultrafiltration. | Van Oss, CJ. and Bronson, PM. 1970. Anal Biochem. 36: 464-9. PMID: 4989157
- Hypogammaglobulinaemia associated with normal or increased IgM (the hyper IgM syndrome): a case series review. | Banatvala, N., et al. 1994. Arch Dis Child. 71: 150-2. PMID: 7944538
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgM Antibody (A-7) | sc-373781 | 200 µg/ml | $316.00 | |||
IgM (A-7) Neutralizing Peptide | sc-373781 P | 100 µg/0.5 ml | $68.00 |