IgG₁ Antibody (2C11): sc-52003

IgG1 Antibody (2C11) is a mouse monoclonal IgG1 antibody that detects the IgG1 protein of human origin by immunofluorescence (IF). Anti-IgG1 antibody (2C11) is available as the non-conjugated format, providing researchers with a versatile tool for studying immune responses. IgG1 protein is a crucial component of the immune system, functioning primarily as an antibody that binds to pathogens such as viruses, bacteria, and fungi, thereby facilitating their neutralization and clearance from the body. IgG1 is the most abundant immunoglobulin subclass in serum and plays a vital role in activating the complement system, which enhances the ability of antibodies and phagocytic cells to clear microbes and damaged cells. IgG1 is unique among immunoglobulins as it can cross the placenta, offering passive immunity to the fetus during the early stages of life when its own immune system is still developing. This characteristic underscores the importance of IgG1 in both maternal and neonatal health, making IgG1 (2C11) antibody an essential reagent for studies focused on immunology, vaccine development, and understanding immune responses in various diseases.

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IgG₁ Antibody (2C11) References:

1. Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA.  |  Tucker, PW., et al. 1979. Science. 206: 1299-303. PMID: 117548
2. Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction.  |  Fuchs, S., et al. 2007. Ann N Y Acad Sci. 1110: 550-8. PMID: 17911471
3. Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life.  |  Nair, N., et al. 2007. J Infect Dis. 196: 1339-45. PMID: 17922398
4. Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum.  |  Wuhrer, M., et al. 2007. Proteomics. 7: 4070-81. PMID: 17994628
5. The role of gene deletion in the immunoglobulin heavy chain switch.  |  Rabbitts, TH., et al. 1980. Nature. 283: 351-6. PMID: 6766206
6. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.  |  Sakano, H., et al. 1980. Nature. 286: 676-83. PMID: 6774258
7. Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.  |  Adetugbo, K. 1978. J Biol Chem. 253: 6068-75. PMID: 98524

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgG₁ Antibody (2C11) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-IgG₁ Antibody (2C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgG₁ Antibody (2C11) Specifications

Alternate Product Name: IgG1

Product Clone Name: 2C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: IgG₁

Epitope Species: human

Product Reactivity/Detection: Fc-region of IgG₁

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for IgG₁ Antibody (2C11): N/A

The preferred IgG₁ antibody is IgG₁ Antibody (14G11): sc-69916.