IGFBPL1 Antibody (C-5): sc-398875

IGFBPL1 Antibody (C-5) is a mouse monoclonal IgM antibody that detects IGFBPL1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IGFBPL1 antibody (C-5) is available as a non-conjugated format. IGFBPL1, also known as Insulin-like growth factor-binding protein-like 1, plays a crucial role in regulating insulin-like growth factors (IGFs) availability and activity in the extracellular environment. By binding to IGFs, IGFBPL1 can modulate their interaction with cell surface receptors, thereby influencing cellular responses such as growth and differentiation. IGFBPL1 has been identified as a potential tumor suppressor, with expression often down-regulated in various tumors. IGFBPL1 is predominantly expressed in brain and testis, with lower levels found in prostate, bladder, and lung, highlighting significance in both normal physiology and disease states. Unique structural features of IGFBPL1, including immunoglobulin-like domain and Kazal-like domain, contribute to functional versatility, making IGFBPL1 a valuable target for research in cancer biology and metabolic disorders.

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IGFBPL1 Antibody (C-5) References:

1. Biology of insulin-like growth factors in development.  |  Dupont, J. and Holzenberger, M. 2003. Birth Defects Res C Embryo Today. 69: 257-71. PMID: 14745968
2. Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.  |  Siwanowicz, I., et al. 2005. Structure. 13: 155-67. PMID: 15642270
3. Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties.  |  Cai, Z., et al. 2005. Biochem Biophys Res Commun. 331: 261-6. PMID: 15845387
4. Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes.  |  Smith, P., et al. 2007. Clin Cancer Res. 13: 4061-8. PMID: 17634530
5. Role of the insulin-like growth factor system on an estrogen-dependent cancer phenotype in the MCF-7 human breast cancer cell line.  |  Bradley, LM., et al. 2008. J Steroid Biochem Mol Biol. 109: 185-96. PMID: 18337089
6. Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy.  |  McIntyre, HD., et al. 2010. Diabetes Care. 33: 356-60. PMID: 19880583
7. IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men.  |  Yeap, BB., et al. 2010. Eur J Endocrinol. 162: 249-57. PMID: 19917654
8. Plasma levels of insulin-like growth factor-I, insulin-like growth factor binding protein-1, coenzyme Q10 and vitamin E in female populations from Poland, Serbia and Sweden.  |  Tekle, M., et al. 2010. Environ Int. 36: 188-94. PMID: 20015549
9. IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort.  |  Verheus, M., et al. 2010. Int J Cancer. 127: 1115-23. PMID: 20039319
10. Common genetic variation of insulin-like growth factor-binding protein 1 (IGFBP-1), IGFBP-3, and acid labile subunit in relation to serum IGF-I levels and mammographic density.  |  Taverne, CW., et al. 2010. Breast Cancer Res Treat. 123: 843-55. PMID: 20155489

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGFBPL1 Antibody (C-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IGFBPL1 Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGFBPL1 Antibody (C-5) Specifications

Alternate Product Name: IGFBPL1

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 45-61

Epitope Target: IGFBPL1

Epitope Species: mouse

Product Reactivity/Detection: IGFBPL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IGFBPL1 Antibody (C-5): P: Blocking Peptide